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NK and trophoblast cells interaction : cytotoxic activity on recurrent pregnancy loss. / Sokolov, Dmitriy I.; Mikhailova, Valentina A.; Agnayeva, Alana O.; Bazhenov, Dmitry O.; Khokhlova, Evgeniya V.; Bespalova, Olesya N.; Gzgzyan, Aleksandr M.; Selkov, Sergey A.

In: Gynecological Endocrinology, Vol. 35, No. sup1, 31.07.2019, p. 5-10.

Research output: Contribution to journalArticlepeer-review

Harvard

Sokolov, DI, Mikhailova, VA, Agnayeva, AO, Bazhenov, DO, Khokhlova, EV, Bespalova, ON, Gzgzyan, AM & Selkov, SA 2019, 'NK and trophoblast cells interaction: cytotoxic activity on recurrent pregnancy loss', Gynecological Endocrinology, vol. 35, no. sup1, pp. 5-10. https://doi.org/10.1080/09513590.2019.1632084

APA

Sokolov, D. I., Mikhailova, V. A., Agnayeva, A. O., Bazhenov, D. O., Khokhlova, E. V., Bespalova, O. N., Gzgzyan, A. M., & Selkov, S. A. (2019). NK and trophoblast cells interaction: cytotoxic activity on recurrent pregnancy loss. Gynecological Endocrinology, 35(sup1), 5-10. https://doi.org/10.1080/09513590.2019.1632084

Vancouver

Sokolov DI, Mikhailova VA, Agnayeva AO, Bazhenov DO, Khokhlova EV, Bespalova ON et al. NK and trophoblast cells interaction: cytotoxic activity on recurrent pregnancy loss. Gynecological Endocrinology. 2019 Jul 31;35(sup1):5-10. https://doi.org/10.1080/09513590.2019.1632084

Author

Sokolov, Dmitriy I. ; Mikhailova, Valentina A. ; Agnayeva, Alana O. ; Bazhenov, Dmitry O. ; Khokhlova, Evgeniya V. ; Bespalova, Olesya N. ; Gzgzyan, Aleksandr M. ; Selkov, Sergey A. / NK and trophoblast cells interaction : cytotoxic activity on recurrent pregnancy loss. In: Gynecological Endocrinology. 2019 ; Vol. 35, No. sup1. pp. 5-10.

BibTeX

@article{a1aa565017164ea2893cebd38e86d165,
title = "NK and trophoblast cells interaction: cytotoxic activity on recurrent pregnancy loss",
abstract = "The trial objective was to determine the peripheral blood NK cells cytotoxic activity effect on trophoblast cells at recurrent pregnancy loss (RPL). The investigation involved non-pregnant women with PRL in proliferating and secretory menstrual cycle phases (PMCPh and SMCPh, respectively); women of 6–7 weeks pregnancy with RPL in past medical history; healthy fertile non-pregnant women in PMCPh and SMCPh, women of 6–7 weeks physiological pregnancy, nulliparity healthy women with regular menstrual function in PMCPh and SMCPh. NK cells cytotoxic activity was determined using peripheral blood mononuclear cells. The target cells were JEG-3 line trophoblasts. It has been established that NK cells cytotoxic activity effect on trophoblasts is lower in SMCPh than in PMCPh in non-pregnant fertile women. The NK cells cytotoxic activity was higher in SMCPh than in PMCPh in non-pregnant women with PRL and also higher than the same value in SMCPh in non-pregnant fertile women. The increased NK cells cytotoxic activity values in SMCPh in women with RPL may be the reason for miscarriage.",
keywords = "cytotoxic activity, miscarriage, NK cells, peripheral blood, pregnancy, recurrent pregnancy loss, trophoblast",
author = "Sokolov, {Dmitriy I.} and Mikhailova, {Valentina A.} and Agnayeva, {Alana O.} and Bazhenov, {Dmitry O.} and Khokhlova, {Evgeniya V.} and Bespalova, {Olesya N.} and Gzgzyan, {Aleksandr M.} and Selkov, {Sergey A.}",
note = "Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Informa UK Limited, trading as Taylor & Francis Group. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
month = jul,
day = "31",
doi = "10.1080/09513590.2019.1632084",
language = "English",
volume = "35",
pages = "5--10",
journal = "Gynecological Endocrinology",
issn = "0951-3590",
publisher = "Taylor & Francis",
number = "sup1",

}

RIS

TY - JOUR

T1 - NK and trophoblast cells interaction

T2 - cytotoxic activity on recurrent pregnancy loss

AU - Sokolov, Dmitriy I.

AU - Mikhailova, Valentina A.

AU - Agnayeva, Alana O.

AU - Bazhenov, Dmitry O.

AU - Khokhlova, Evgeniya V.

AU - Bespalova, Olesya N.

AU - Gzgzyan, Aleksandr M.

AU - Selkov, Sergey A.

N1 - Publisher Copyright: © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019/7/31

Y1 - 2019/7/31

N2 - The trial objective was to determine the peripheral blood NK cells cytotoxic activity effect on trophoblast cells at recurrent pregnancy loss (RPL). The investigation involved non-pregnant women with PRL in proliferating and secretory menstrual cycle phases (PMCPh and SMCPh, respectively); women of 6–7 weeks pregnancy with RPL in past medical history; healthy fertile non-pregnant women in PMCPh and SMCPh, women of 6–7 weeks physiological pregnancy, nulliparity healthy women with regular menstrual function in PMCPh and SMCPh. NK cells cytotoxic activity was determined using peripheral blood mononuclear cells. The target cells were JEG-3 line trophoblasts. It has been established that NK cells cytotoxic activity effect on trophoblasts is lower in SMCPh than in PMCPh in non-pregnant fertile women. The NK cells cytotoxic activity was higher in SMCPh than in PMCPh in non-pregnant women with PRL and also higher than the same value in SMCPh in non-pregnant fertile women. The increased NK cells cytotoxic activity values in SMCPh in women with RPL may be the reason for miscarriage.

AB - The trial objective was to determine the peripheral blood NK cells cytotoxic activity effect on trophoblast cells at recurrent pregnancy loss (RPL). The investigation involved non-pregnant women with PRL in proliferating and secretory menstrual cycle phases (PMCPh and SMCPh, respectively); women of 6–7 weeks pregnancy with RPL in past medical history; healthy fertile non-pregnant women in PMCPh and SMCPh, women of 6–7 weeks physiological pregnancy, nulliparity healthy women with regular menstrual function in PMCPh and SMCPh. NK cells cytotoxic activity was determined using peripheral blood mononuclear cells. The target cells were JEG-3 line trophoblasts. It has been established that NK cells cytotoxic activity effect on trophoblasts is lower in SMCPh than in PMCPh in non-pregnant fertile women. The NK cells cytotoxic activity was higher in SMCPh than in PMCPh in non-pregnant women with PRL and also higher than the same value in SMCPh in non-pregnant fertile women. The increased NK cells cytotoxic activity values in SMCPh in women with RPL may be the reason for miscarriage.

KW - cytotoxic activity

KW - miscarriage

KW - NK cells

KW - peripheral blood

KW - pregnancy

KW - recurrent pregnancy loss

KW - trophoblast

UR - http://www.scopus.com/inward/record.url?scp=85072292021&partnerID=8YFLogxK

U2 - 10.1080/09513590.2019.1632084

DO - 10.1080/09513590.2019.1632084

M3 - Article

C2 - 31532308

AN - SCOPUS:85072292021

VL - 35

SP - 5

EP - 10

JO - Gynecological Endocrinology

JF - Gynecological Endocrinology

SN - 0951-3590

IS - sup1

ER -

ID: 76494483