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New water-soluble dosage forms of 1,2,4-thiadiazole derivative on the basis of inclusion complexes with cyclodextrins. / Brusnikina, Maria; Silyukov, Oleg; Chislov, Mikhail; Volkova, Tatyana; Proshin, Alexey; Terekhova, Irina.

In: Journal of Thermal Analysis and Calorimetry, Vol. 127, No. 2, 01.02.2017, p. 1815-1824.

Research output: Contribution to journal › Article › peer-review

Harvard

Brusnikina, M, Silyukov, O, Chislov, M, Volkova, T, Proshin, A & Terekhova, I 2017, 'New water-soluble dosage forms of 1,2,4-thiadiazole derivative on the basis of inclusion complexes with cyclodextrins', Journal of Thermal Analysis and Calorimetry, vol. 127, no. 2, pp. 1815-1824. https://doi.org/10.1007/s10973-016-5955-z

APA

Brusnikina, M., Silyukov, O., Chislov, M., Volkova, T., Proshin, A., & Terekhova, I. (2017). New water-soluble dosage forms of 1,2,4-thiadiazole derivative on the basis of inclusion complexes with cyclodextrins. Journal of Thermal Analysis and Calorimetry, 127(2), 1815-1824. https://doi.org/10.1007/s10973-016-5955-z

Vancouver

Brusnikina M, Silyukov O, Chislov M, Volkova T, Proshin A, Terekhova I. New water-soluble dosage forms of 1,2,4-thiadiazole derivative on the basis of inclusion complexes with cyclodextrins. Journal of Thermal Analysis and Calorimetry. 2017 Feb 1;127(2):1815-1824. https://doi.org/10.1007/s10973-016-5955-z

Author

Brusnikina, Maria ; Silyukov, Oleg ; Chislov, Mikhail ; Volkova, Tatyana ; Proshin, Alexey ; Terekhova, Irina. / New water-soluble dosage forms of 1,2,4-thiadiazole derivative on the basis of inclusion complexes with cyclodextrins. In: Journal of Thermal Analysis and Calorimetry. 2017 ; Vol. 127, No. 2. pp. 1815-1824.

BibTeX

@article{30ab529abe4f4bf7abb691a74776e82c,
title = "New water-soluble dosage forms of 1,2,4-thiadiazole derivative on the basis of inclusion complexes with cyclodextrins",
abstract = "Effect of cyclodextrins on aqueous solubility of 1-[5-(3-chloro-phenylamino)-1,2,4-thiadiazol-3-yl]-propan-2-ol (I), which was synthesized and proposed for the treatment of Alzheimer{\textquoteright}s disease, was studied. First of all, inclusion complex formation of I with different cyclodextrins was studied in aqueous solutions. Formation of more stable complexes with β- and hydroxypropyl-β-cyclodextrins was revealed. Next, solid inclusion complexes of I with β- and hydroxypropyl-β-cyclodextrins were prepared by the mechanical grinding, and their existence in the solid state was confirmed by powder X-ray diffraction, FTIR spectroscopy, microscopy, and thermochemical methods. Dissolution testing of the tablets of pure I and its complexes with β- and hydroxypropyl-β-cyclodextrins in the aqueous buffered solutions simulated the biological environment was carried out. The observed drastic enhancement of dissolution extent and dissolution rate of the complexes was attributed to the inclusion complex formation.",
keywords = "1,2,4-Thiadiazole, Cyclodextrin, Inclusion complex, Thermal analysis, Thermodynamics, Water-soluble dosage forms",
author = "Maria Brusnikina and Oleg Silyukov and Mikhail Chislov and Tatyana Volkova and Alexey Proshin and Irina Terekhova",
year = "2017",
month = feb,
day = "1",
doi = "10.1007/s10973-016-5955-z",
language = "English",
volume = "127",
pages = "1815--1824",
journal = "Journal of Thermal Analysis and Calorimetry",
issn = "1388-6150",
publisher = "Springer Nature",
number = "2",

}

RIS

TY - JOUR

T1 - New water-soluble dosage forms of 1,2,4-thiadiazole derivative on the basis of inclusion complexes with cyclodextrins

AU - Brusnikina, Maria

AU - Silyukov, Oleg

AU - Chislov, Mikhail

AU - Volkova, Tatyana

AU - Proshin, Alexey

AU - Terekhova, Irina

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Effect of cyclodextrins on aqueous solubility of 1-[5-(3-chloro-phenylamino)-1,2,4-thiadiazol-3-yl]-propan-2-ol (I), which was synthesized and proposed for the treatment of Alzheimer’s disease, was studied. First of all, inclusion complex formation of I with different cyclodextrins was studied in aqueous solutions. Formation of more stable complexes with β- and hydroxypropyl-β-cyclodextrins was revealed. Next, solid inclusion complexes of I with β- and hydroxypropyl-β-cyclodextrins were prepared by the mechanical grinding, and their existence in the solid state was confirmed by powder X-ray diffraction, FTIR spectroscopy, microscopy, and thermochemical methods. Dissolution testing of the tablets of pure I and its complexes with β- and hydroxypropyl-β-cyclodextrins in the aqueous buffered solutions simulated the biological environment was carried out. The observed drastic enhancement of dissolution extent and dissolution rate of the complexes was attributed to the inclusion complex formation.

AB - Effect of cyclodextrins on aqueous solubility of 1-[5-(3-chloro-phenylamino)-1,2,4-thiadiazol-3-yl]-propan-2-ol (I), which was synthesized and proposed for the treatment of Alzheimer’s disease, was studied. First of all, inclusion complex formation of I with different cyclodextrins was studied in aqueous solutions. Formation of more stable complexes with β- and hydroxypropyl-β-cyclodextrins was revealed. Next, solid inclusion complexes of I with β- and hydroxypropyl-β-cyclodextrins were prepared by the mechanical grinding, and their existence in the solid state was confirmed by powder X-ray diffraction, FTIR spectroscopy, microscopy, and thermochemical methods. Dissolution testing of the tablets of pure I and its complexes with β- and hydroxypropyl-β-cyclodextrins in the aqueous buffered solutions simulated the biological environment was carried out. The observed drastic enhancement of dissolution extent and dissolution rate of the complexes was attributed to the inclusion complex formation.

KW - 1,2,4-Thiadiazole

KW - Cyclodextrin

KW - Inclusion complex

KW - Thermal analysis

KW - Thermodynamics

KW - Water-soluble dosage forms

UR - http://www.scopus.com/inward/record.url?scp=84996486486&partnerID=8YFLogxK

U2 - 10.1007/s10973-016-5955-z

DO - 10.1007/s10973-016-5955-z

M3 - Article

AN - SCOPUS:84996486486

VL - 127

SP - 1815

EP - 1824

JO - Journal of Thermal Analysis and Calorimetry

JF - Journal of Thermal Analysis and Calorimetry

SN - 1388-6150

IS - 2

ER -

ID: 37016598