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New laboratory criteria of the autoimmune inflammation in pulmonary sarcoidosis and tuberculosis. / Малкова, Анна Михайловна; Старшинова, Анна Андреевна; Зинченко, Юлия Сергеевна; Гаврилова, Наталия Юрьевна; Кудрявцев, Игорь Владимирович; Лапин, Сергей Владимирович; Мазинг, Александра Васильевна; Суркова, Е.А.; Павлова, М; Беляева, Е; Степаненко, Т; Яблонский, Петр Казимирович; Шенфельд, Иегуда Юлиус.

In: Clinical Immunology, Vol. 227, 108724, 06.2021, p. 227:108724.

Research output: Contribution to journal › Article › peer-review

Harvard

Малкова, АМ, Старшинова, АА, Зинченко, ЮС, Гаврилова, НЮ, Кудрявцев, ИВ, Лапин, СВ, Мазинг, АВ, Суркова, ЕА, Павлова, М, Беляева, Е, Степаненко, Т, Яблонский, ПК & Шенфельд, ИЮ 2021, 'New laboratory criteria of the autoimmune inflammation in pulmonary sarcoidosis and tuberculosis', Clinical Immunology, vol. 227, 108724, pp. 227:108724. https://doi.org/10.1016/j.clim.2021.108724

APA

Малкова, А. М., Старшинова, А. А., Зинченко, Ю. С., Гаврилова, Н. Ю., Кудрявцев, И. В., Лапин, С. В., Мазинг, А. В., Суркова, Е. А., Павлова, М., Беляева, Е., Степаненко, Т., Яблонский, П. К., & Шенфельд, И. Ю. (2021). New laboratory criteria of the autoimmune inflammation in pulmonary sarcoidosis and tuberculosis. Clinical Immunology, 227, 227:108724. [108724]. https://doi.org/10.1016/j.clim.2021.108724

Vancouver

Малкова АМ, Старшинова АА, Зинченко ЮС, Гаврилова НЮ, Кудрявцев ИВ, Лапин СВ et al. New laboratory criteria of the autoimmune inflammation in pulmonary sarcoidosis and tuberculosis. Clinical Immunology. 2021 Jun;227:227:108724. 108724. https://doi.org/10.1016/j.clim.2021.108724

Author

Малкова, Анна Михайловна ; Старшинова, Анна Андреевна ; Зинченко, Юлия Сергеевна ; Гаврилова, Наталия Юрьевна ; Кудрявцев, Игорь Владимирович ; Лапин, Сергей Владимирович ; Мазинг, Александра Васильевна ; Суркова, Е.А. ; Павлова, М ; Беляева, Е ; Степаненко, Т ; Яблонский, Петр Казимирович ; Шенфельд, Иегуда Юлиус. / New laboratory criteria of the autoimmune inflammation in pulmonary sarcoidosis and tuberculosis. In: Clinical Immunology. 2021 ; Vol. 227. pp. 227:108724.

BibTeX

@article{5381265806cb44afa92b5ff219022636,
title = "New laboratory criteria of the autoimmune inflammation in pulmonary sarcoidosis and tuberculosis",
abstract = "Sarcoidosis and tuberculosis have many clinical and laboratory similarities, which allowed researchers to assume the presence of common pathogenetic mechanisms in the development of both diseases. Recently, much attention has been paid to investigate the autoimmune origins in these pathologies. The aim of this study is to find out the characteristics of the autoinflammatory immune response in sarcoidosis and tuberculosis. In patients with sarcoidosis (n = 93), tuberculosis (n = 28), and in healthy donors (n = 40), the serum anti-MCV concentration was measured by ELISA, and B cell subpopulations were analyzed by flow cytometry. Based on the results obtained, the formula ([B-na{\"i}ve%]\[B-memory%]) * ([B-CD38%] + [B-CD5%]) / [anti-MCV] was described. The increase in the calculated index by more than 5 units with a sensitivity of 80.00% and a specificity of 93.10% (AUC = 0.926) suggest the presence of the autoimmune component, which is more typical for sarcoidosis, rather than tuberculosis patients and may serve as a diagnostic criterion.",
keywords = "Autoimmune response, Diagnostic criteria, Sarcoidosis, Tuberculosis, ETIOLOGY, IDENTIFICATION, MYCOBACTERIAL CATALASE-PEROXIDASE, PEPTIDES, VIMENTIN, B-CELL POPULATIONS, INFECTION, MOLECULAR MIMICRY, HLA, ANTIGEN",
author = "Малкова, {Анна Михайловна} and Старшинова, {Анна Андреевна} and Зинченко, {Юлия Сергеевна} and Гаврилова, {Наталия Юрьевна} and Кудрявцев, {Игорь Владимирович} and Лапин, {Сергей Владимирович} and Мазинг, {Александра Васильевна} and Е.А. Суркова and М Павлова and Е Беляева and Т Степаненко and Яблонский, {Петр Казимирович} and Шенфельд, {Иегуда Юлиус}",
note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = jun,
doi = "10.1016/j.clim.2021.108724",
language = "English",
volume = "227",
pages = "227:108724",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - New laboratory criteria of the autoimmune inflammation in pulmonary sarcoidosis and tuberculosis

AU - Малкова, Анна Михайловна

AU - Старшинова, Анна Андреевна

AU - Зинченко, Юлия Сергеевна

AU - Гаврилова, Наталия Юрьевна

AU - Кудрявцев, Игорь Владимирович

AU - Лапин, Сергей Владимирович

AU - Мазинг, Александра Васильевна

AU - Суркова, Е.А.

AU - Павлова, М

AU - Беляева, Е

AU - Степаненко, Т

AU - Яблонский, Петр Казимирович

AU - Шенфельд, Иегуда Юлиус

N1 - Publisher Copyright: © 2021 Elsevier Inc.

PY - 2021/6

Y1 - 2021/6

N2 - Sarcoidosis and tuberculosis have many clinical and laboratory similarities, which allowed researchers to assume the presence of common pathogenetic mechanisms in the development of both diseases. Recently, much attention has been paid to investigate the autoimmune origins in these pathologies. The aim of this study is to find out the characteristics of the autoinflammatory immune response in sarcoidosis and tuberculosis. In patients with sarcoidosis (n = 93), tuberculosis (n = 28), and in healthy donors (n = 40), the serum anti-MCV concentration was measured by ELISA, and B cell subpopulations were analyzed by flow cytometry. Based on the results obtained, the formula ([B-naïve%]\[B-memory%]) * ([B-CD38%] + [B-CD5%]) / [anti-MCV] was described. The increase in the calculated index by more than 5 units with a sensitivity of 80.00% and a specificity of 93.10% (AUC = 0.926) suggest the presence of the autoimmune component, which is more typical for sarcoidosis, rather than tuberculosis patients and may serve as a diagnostic criterion.

AB - Sarcoidosis and tuberculosis have many clinical and laboratory similarities, which allowed researchers to assume the presence of common pathogenetic mechanisms in the development of both diseases. Recently, much attention has been paid to investigate the autoimmune origins in these pathologies. The aim of this study is to find out the characteristics of the autoinflammatory immune response in sarcoidosis and tuberculosis. In patients with sarcoidosis (n = 93), tuberculosis (n = 28), and in healthy donors (n = 40), the serum anti-MCV concentration was measured by ELISA, and B cell subpopulations were analyzed by flow cytometry. Based on the results obtained, the formula ([B-naïve%]\[B-memory%]) * ([B-CD38%] + [B-CD5%]) / [anti-MCV] was described. The increase in the calculated index by more than 5 units with a sensitivity of 80.00% and a specificity of 93.10% (AUC = 0.926) suggest the presence of the autoimmune component, which is more typical for sarcoidosis, rather than tuberculosis patients and may serve as a diagnostic criterion.

KW - Autoimmune response

KW - Diagnostic criteria

KW - Sarcoidosis

KW - Tuberculosis

KW - ETIOLOGY

KW - IDENTIFICATION

KW - MYCOBACTERIAL CATALASE-PEROXIDASE

KW - PEPTIDES

KW - VIMENTIN

KW - B-CELL POPULATIONS

KW - INFECTION

KW - MOLECULAR MIMICRY

KW - HLA

KW - ANTIGEN

UR - http://www.scopus.com/inward/record.url?scp=85106633854&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/41623ad1-54ac-3d25-856d-e447861b9031/

U2 - 10.1016/j.clim.2021.108724

DO - 10.1016/j.clim.2021.108724

M3 - Article

VL - 227

SP - 227:108724

JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

M1 - 108724

ER -

ID: 85023454