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Neurotranscriptomic and behavioral effects of ISRIB, and its therapeutic effects in the traumatic brain injury model in zebrafish. / Ilyin, Nikita P.; Shevlyakov, Anton D.; Boyko, Galina A.; Moskalenko, Anastasia M.; Ikrin, Aleksey N.; Galstyan, David S.; Kolesnikova, Tatiana O.; Katolikova, Nataliia V.; Chekrygin, Sergei A.; Lim, Lee Wei; Yang, LongEn; De Abreu, Murilo S.; Yenkoyan, Konstantin B.; Kalueff, Allan V.; Demin, Konstantin A.

In: Brain Research, Vol. 1848, 149329, 01.02.2025.

Research output: Contribution to journal › Article › peer-review

Harvard

Ilyin, NP, Shevlyakov, AD, Boyko, GA, Moskalenko, AM, Ikrin, AN, Galstyan, DS, Kolesnikova, TO, Katolikova, NV, Chekrygin, SA, Lim, LW, Yang, L, De Abreu, MS, Yenkoyan, KB, Kalueff, AV & Demin, KA 2025, 'Neurotranscriptomic and behavioral effects of ISRIB, and its therapeutic effects in the traumatic brain injury model in zebrafish', Brain Research, vol. 1848, 149329. https://doi.org/10.1016/j.brainres.2024.149329, https://doi.org/10.1016/j.brainres.2024.149329

APA

Ilyin, N. P., Shevlyakov, A. D., Boyko, G. A., Moskalenko, A. M., Ikrin, A. N., Galstyan, D. S., Kolesnikova, T. O., Katolikova, N. V., Chekrygin, S. A., Lim, L. W., Yang, L., De Abreu, M. S., Yenkoyan, K. B., Kalueff, A. V., & Demin, K. A. (2025). Neurotranscriptomic and behavioral effects of ISRIB, and its therapeutic effects in the traumatic brain injury model in zebrafish. Brain Research, 1848, [149329]. https://doi.org/10.1016/j.brainres.2024.149329, https://doi.org/10.1016/j.brainres.2024.149329

Vancouver

Ilyin NP, Shevlyakov AD, Boyko GA, Moskalenko AM, Ikrin AN, Galstyan DS et al. Neurotranscriptomic and behavioral effects of ISRIB, and its therapeutic effects in the traumatic brain injury model in zebrafish. Brain Research. 2025 Feb 1;1848. 149329. https://doi.org/10.1016/j.brainres.2024.149329, https://doi.org/10.1016/j.brainres.2024.149329

Author

Ilyin, Nikita P. ; Shevlyakov, Anton D. ; Boyko, Galina A. ; Moskalenko, Anastasia M. ; Ikrin, Aleksey N. ; Galstyan, David S. ; Kolesnikova, Tatiana O. ; Katolikova, Nataliia V. ; Chekrygin, Sergei A. ; Lim, Lee Wei ; Yang, LongEn ; De Abreu, Murilo S. ; Yenkoyan, Konstantin B. ; Kalueff, Allan V. ; Demin, Konstantin A. / Neurotranscriptomic and behavioral effects of ISRIB, and its therapeutic effects in the traumatic brain injury model in zebrafish. In: Brain Research. 2025 ; Vol. 1848.

BibTeX

@article{6f9f4516a450476b894c73a55bef466d,
title = "Neurotranscriptomic and behavioral effects of ISRIB, and its therapeutic effects in the traumatic brain injury model in zebrafish",
abstract = "Traumatic brain injury (TBI) is a global medical concern and has a lasting impact on brain activity with high risks of mortality. Current treatments are inadequate for repairing damaged brain cells or correcting cognitive and behavioral disabilities in TBI patients. Mounting evidence links TBI to the activation of the Integrated Stress Response (ISR) signaling in the brain. A novel small molecule, ISRIB, is an effective inhibitor of the ISR pathway, offering potential advantages for brain health. Here, we investigated how ISRIB affects brain transcriptome and behavior in zebrafish TBI model evoked by telencephalic brain injury. Overall, while TBI diminished memory and social behavior in zebrafish, administering ISRIB post-injury markedly reduced these behavioral deficits, and modulated brain gene expression, rescuing TBI-activated pathways related to inflammation and brain cell development. Collectively, this supports the role of brain ISR in TBI, and suggests potential utility of ISRIB for the treatment of TBI-related states.",
keywords = "Behavioral deficits, ISRIB, Integrated Stress Response, Transcriptome, Traumatic brain injury, Zebrafish",
author = "Ilyin, {Nikita P.} and Shevlyakov, {Anton D.} and Boyko, {Galina A.} and Moskalenko, {Anastasia M.} and Ikrin, {Aleksey N.} and Galstyan, {David S.} and Kolesnikova, {Tatiana O.} and Katolikova, {Nataliia V.} and Chekrygin, {Sergei A.} and Lim, {Lee Wei} and LongEn Yang and {De Abreu}, {Murilo S.} and Yenkoyan, {Konstantin B.} and Kalueff, {Allan V.} and Demin, {Konstantin A.}",
year = "2025",
month = feb,
day = "1",
doi = "10.1016/j.brainres.2024.149329",
language = "English",
volume = "1848",
journal = "Molecular Brain Research",
issn = "0006-8993",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Neurotranscriptomic and behavioral effects of ISRIB, and its therapeutic effects in the traumatic brain injury model in zebrafish

AU - Ilyin, Nikita P.

AU - Shevlyakov, Anton D.

AU - Boyko, Galina A.

AU - Moskalenko, Anastasia M.

AU - Ikrin, Aleksey N.

AU - Galstyan, David S.

AU - Kolesnikova, Tatiana O.

AU - Katolikova, Nataliia V.

AU - Chekrygin, Sergei A.

AU - Lim, Lee Wei

AU - Yang, LongEn

AU - De Abreu, Murilo S.

AU - Yenkoyan, Konstantin B.

AU - Kalueff, Allan V.

AU - Demin, Konstantin A.

PY - 2025/2/1

Y1 - 2025/2/1

N2 - Traumatic brain injury (TBI) is a global medical concern and has a lasting impact on brain activity with high risks of mortality. Current treatments are inadequate for repairing damaged brain cells or correcting cognitive and behavioral disabilities in TBI patients. Mounting evidence links TBI to the activation of the Integrated Stress Response (ISR) signaling in the brain. A novel small molecule, ISRIB, is an effective inhibitor of the ISR pathway, offering potential advantages for brain health. Here, we investigated how ISRIB affects brain transcriptome and behavior in zebrafish TBI model evoked by telencephalic brain injury. Overall, while TBI diminished memory and social behavior in zebrafish, administering ISRIB post-injury markedly reduced these behavioral deficits, and modulated brain gene expression, rescuing TBI-activated pathways related to inflammation and brain cell development. Collectively, this supports the role of brain ISR in TBI, and suggests potential utility of ISRIB for the treatment of TBI-related states.

AB - Traumatic brain injury (TBI) is a global medical concern and has a lasting impact on brain activity with high risks of mortality. Current treatments are inadequate for repairing damaged brain cells or correcting cognitive and behavioral disabilities in TBI patients. Mounting evidence links TBI to the activation of the Integrated Stress Response (ISR) signaling in the brain. A novel small molecule, ISRIB, is an effective inhibitor of the ISR pathway, offering potential advantages for brain health. Here, we investigated how ISRIB affects brain transcriptome and behavior in zebrafish TBI model evoked by telencephalic brain injury. Overall, while TBI diminished memory and social behavior in zebrafish, administering ISRIB post-injury markedly reduced these behavioral deficits, and modulated brain gene expression, rescuing TBI-activated pathways related to inflammation and brain cell development. Collectively, this supports the role of brain ISR in TBI, and suggests potential utility of ISRIB for the treatment of TBI-related states.

KW - Behavioral deficits

KW - ISRIB

KW - Integrated Stress Response

KW - Transcriptome

KW - Traumatic brain injury

KW - Zebrafish

UR - https://www.mendeley.com/catalogue/c42788ea-c79b-3324-bcdc-451ddc21c9b6/

U2 - 10.1016/j.brainres.2024.149329

DO - 10.1016/j.brainres.2024.149329

M3 - Article

VL - 1848

JO - Molecular Brain Research

JF - Molecular Brain Research

SN - 0006-8993

M1 - 149329

ER -

ID: 127836530