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Neuroplastic and Neuroinflammatory Alterations in the Hippocampus after Spinal Cord Injury. / Коновалова, Софья; Сысоев, Юрий Игоревич; Шкорбатова, Полина Юрьевна; Ветлугина, Анастасия; Штоль В.С.; Арсентьев К.; Stepanichev, M.Yu. ; Оковитый, Сергей Владимирович; Мусиенко, Павел Евгеньевич.

In: Cell and Tissue Biology, Vol. 19, No. Suppl. 1, 19.08.2025, p. S127–S137.

Research output: Contribution to journal › Article › peer-review

Harvard

Коновалова, С, Сысоев, ЮИ, Шкорбатова, ПЮ, Ветлугина, А, Штоль В.С., Арсентьев К., Stepanichev, MY, Оковитый, СВ & Мусиенко, ПЕ 2025, 'Neuroplastic and Neuroinflammatory Alterations in the Hippocampus after Spinal Cord Injury', Cell and Tissue Biology, vol. 19, no. Suppl. 1, pp. S127–S137. https://doi.org/10.1134/S1990519X25600383

APA

Коновалова, С., Сысоев, Ю. И., Шкорбатова, П. Ю., Ветлугина, А., Штоль В.С., Арсентьев К., Stepanichev, M. Y., Оковитый, С. В., & Мусиенко, П. Е. (2025). Neuroplastic and Neuroinflammatory Alterations in the Hippocampus after Spinal Cord Injury. Cell and Tissue Biology, 19(Suppl. 1), S127–S137. https://doi.org/10.1134/S1990519X25600383

Vancouver

Коновалова С, Сысоев ЮИ, Шкорбатова ПЮ, Ветлугина А, Штоль В.С., Арсентьев К. et al. Neuroplastic and Neuroinflammatory Alterations in the Hippocampus after Spinal Cord Injury. Cell and Tissue Biology. 2025 Aug 19;19(Suppl. 1):S127–S137. https://doi.org/10.1134/S1990519X25600383

Author

Коновалова, Софья ; Сысоев, Юрий Игоревич ; Шкорбатова, Полина Юрьевна ; Ветлугина, Анастасия ; Штоль В.С. ; Арсентьев К. ; Stepanichev, M.Yu. ; Оковитый, Сергей Владимирович ; Мусиенко, Павел Евгеньевич. / Neuroplastic and Neuroinflammatory Alterations in the Hippocampus after Spinal Cord Injury. In: Cell and Tissue Biology. 2025 ; Vol. 19, No. Suppl. 1. pp. S127–S137.

BibTeX

@article{e829d9918c8c4beba3121dadae62318e,
title = "Neuroplastic and Neuroinflammatory Alterations in the Hippocampus after Spinal Cord Injury",
abstract = "Abstract: Objective: Spinal cord injury (SCI) is a debilitating condition that not only affects motor and sensory functions, but also causes widespread neuroplastic and neuroinflammatory changes in the hippocampus, a brain region critical for learning and memory. Methods: This study examined region-specific changes in hippocampal subregions (CA1, CA3, and dentate gyrus) in a rat model of SCI, evaluating neurogenesis, microglial and astroglial cell activation, and behavioral outcomes. Results and Discussion: The study revealed distinct patterns of neuroplastic and neuroinflammatory changes in hippocampal subregions, with some areas showing increased susceptibility to injury-induced changes. Behavioral analyses showed a significant correlation between these hippocampal changes and impairments in memory and learning ability, highlighting the functional consequences of SCI on cognitive processes. Conclusions: The findings emphasize the importance of understanding the relationship between neuroplasticity and neuroinflammation in the hippocampus after SCI, which may facilitate the development of targeted therapeutic strategies to mitigate cognitive deficits.",
keywords = "spinal cord injury, neuroinflammation, hippocampus, memory, rats, spinal cord injury, memory, hippocampus, neuroinflammation, rats",
author = "Софья Коновалова and Сысоев, {Юрий Игоревич} and Шкорбатова, {Полина Юрьевна} and Анастасия Ветлугина and {Штоль В.С.} and {Арсентьев К.} and M.Yu. Stepanichev and Оковитый, {Сергей Владимирович} and Мусиенко, {Павел Евгеньевич}",
year = "2025",
month = aug,
day = "19",
doi = "10.1134/S1990519X25600383",
language = "English",
volume = "19",
pages = "S127–S137",
journal = "Cell and Tissue Biology",
issn = "1990-519X",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "Suppl. 1",

}

RIS

TY - JOUR

T1 - Neuroplastic and Neuroinflammatory Alterations in the Hippocampus after Spinal Cord Injury

AU - Коновалова, Софья

AU - Сысоев, Юрий Игоревич

AU - Шкорбатова, Полина Юрьевна

AU - Ветлугина, Анастасия

AU - Штоль В.С.,

AU - Арсентьев К., null

AU - Stepanichev, M.Yu.

AU - Оковитый, Сергей Владимирович

AU - Мусиенко, Павел Евгеньевич

PY - 2025/8/19

Y1 - 2025/8/19

N2 - Abstract: Objective: Spinal cord injury (SCI) is a debilitating condition that not only affects motor and sensory functions, but also causes widespread neuroplastic and neuroinflammatory changes in the hippocampus, a brain region critical for learning and memory. Methods: This study examined region-specific changes in hippocampal subregions (CA1, CA3, and dentate gyrus) in a rat model of SCI, evaluating neurogenesis, microglial and astroglial cell activation, and behavioral outcomes. Results and Discussion: The study revealed distinct patterns of neuroplastic and neuroinflammatory changes in hippocampal subregions, with some areas showing increased susceptibility to injury-induced changes. Behavioral analyses showed a significant correlation between these hippocampal changes and impairments in memory and learning ability, highlighting the functional consequences of SCI on cognitive processes. Conclusions: The findings emphasize the importance of understanding the relationship between neuroplasticity and neuroinflammation in the hippocampus after SCI, which may facilitate the development of targeted therapeutic strategies to mitigate cognitive deficits.

AB - Abstract: Objective: Spinal cord injury (SCI) is a debilitating condition that not only affects motor and sensory functions, but also causes widespread neuroplastic and neuroinflammatory changes in the hippocampus, a brain region critical for learning and memory. Methods: This study examined region-specific changes in hippocampal subregions (CA1, CA3, and dentate gyrus) in a rat model of SCI, evaluating neurogenesis, microglial and astroglial cell activation, and behavioral outcomes. Results and Discussion: The study revealed distinct patterns of neuroplastic and neuroinflammatory changes in hippocampal subregions, with some areas showing increased susceptibility to injury-induced changes. Behavioral analyses showed a significant correlation between these hippocampal changes and impairments in memory and learning ability, highlighting the functional consequences of SCI on cognitive processes. Conclusions: The findings emphasize the importance of understanding the relationship between neuroplasticity and neuroinflammation in the hippocampus after SCI, which may facilitate the development of targeted therapeutic strategies to mitigate cognitive deficits.

KW - spinal cord injury, neuroinflammation, hippocampus, memory, rats

KW - spinal cord injury

KW - memory

KW - hippocampus

KW - neuroinflammation

KW - rats

UR - https://www.mendeley.com/catalogue/76af35a7-56c3-3f1b-86a5-1130976527f4/

U2 - 10.1134/S1990519X25600383

DO - 10.1134/S1990519X25600383

M3 - Article

VL - 19

SP - S127–S137

JO - Cell and Tissue Biology

JF - Cell and Tissue Biology

SN - 1990-519X

IS - Suppl. 1

ER -

ID: 137732347