TY - JOUR

T1 - Neurocognitive and behavioural effects of sage-leaved rock-rose Cistus salviifolius L. extract in experimental non-alcoholic steatohepatitis

AU - Prikhodko, V.A.

AU - Orlyakhina, D.A.

AU - Petrova, V.D.

AU - Semivelichenko, E.D.

AU - Plisko, G.A.

AU - Karev, V.E.

AU - Ivkin, D.Yu.

AU - Okovityi, S.V.

N1 - Export Date: 21 October 2024 Адрес для корреспонденции: Prikhodko, V.A.; Saint Petersburg State Chemical and Pharmaceutical University, 4 Prof. Popov str., Russian Federation; эл. почта: veronika.prihodko@pharminnotech.com Химические вещества/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; acetylcholine, 51-84-3, 60-31-1, 66-23-9; eosin, 17372-87-1, 51395-88-1, 548-26-5; hematoxylin, 517-28-2 Фирменные наименования: Prism 9.0.0, Graphpad, United States; R 4.1.1, R Foundation, Austria; RStudio 1.4.1717, R Foundation, Austria; VideoMot2 3.0.1, TSE Systems, Germany Производители: R Foundation, Austria; TSE Systems, Germany; Graphpad, United States

PY - 2024

Y1 - 2024

N2 - Non-alcoholic steatohepatitis (NASH) is the leading cause of chronic liver disease in the modern world. Besides metabolic and cardiovascular comorbidities, NASH is associated with increased prevalence of neurocognitive and psychiatric disorders. Sage-leaved rock-rose Cistus salviifolius L. (CS) is a plant with a wide spectrum of biological activities including possible psychotropic and procognitive effects. In view of the above, the present study was aimed at exploring the potential therapeutic effects of a CS aqueous extract in behavioural and memory dysfunction associated with experimental murine alimentary/ toxic NASH. 90 male C57Bl/6 mice were randomized into the following groups: (1) Control: NASH + no treatment; (2) CS253: NASH + 253 mg·kg-1 b.w. CS ex-tract; (3) CS506: NASH + 506 mg·kg-1 b.w. CS extract. NASH was induced over 3 months, and the drugs were administered orally q.d. during the experimental period. As assessed by the Open field, Elevated plus maze, and Light/dark box test, both doses of the CS extract induced sedation with possible anxiogenic effect in mice. In addition, the CS extract alleviated spatial memory dysfunction but had no effect on object recognition memory. Possible mechanisms behind the extract’s effects include the potentiation of calcium-dependent neuronal signaling as well as the modulation of central γ-aminobutyric acid, acetylcholine, or monoamine neurotransmission, which requires further elucidation. © 2024 Global Media Technologies. All rights reserved.

AB - Non-alcoholic steatohepatitis (NASH) is the leading cause of chronic liver disease in the modern world. Besides metabolic and cardiovascular comorbidities, NASH is associated with increased prevalence of neurocognitive and psychiatric disorders. Sage-leaved rock-rose Cistus salviifolius L. (CS) is a plant with a wide spectrum of biological activities including possible psychotropic and procognitive effects. In view of the above, the present study was aimed at exploring the potential therapeutic effects of a CS aqueous extract in behavioural and memory dysfunction associated with experimental murine alimentary/ toxic NASH. 90 male C57Bl/6 mice were randomized into the following groups: (1) Control: NASH + no treatment; (2) CS253: NASH + 253 mg·kg-1 b.w. CS ex-tract; (3) CS506: NASH + 506 mg·kg-1 b.w. CS extract. NASH was induced over 3 months, and the drugs were administered orally q.d. during the experimental period. As assessed by the Open field, Elevated plus maze, and Light/dark box test, both doses of the CS extract induced sedation with possible anxiogenic effect in mice. In addition, the CS extract alleviated spatial memory dysfunction but had no effect on object recognition memory. Possible mechanisms behind the extract’s effects include the potentiation of calcium-dependent neuronal signaling as well as the modulation of central γ-aminobutyric acid, acetylcholine, or monoamine neurotransmission, which requires further elucidation. © 2024 Global Media Technologies. All rights reserved.

KW - anxiety

KW - behavioural testing

KW - CistussalviifoliusL

KW - cognitive dysfunction

KW - memory deficits

KW - mice

KW - non-alcoholic steatohepatitis

KW - sedative agents

KW - 4 aminobutyric acid

KW - acetylcholine

KW - Cistus salviifolius

KW - eosin

KW - hematoxylin

KW - monoamine

KW - plant extract

KW - sedative agent

KW - unclassified drug

KW - adult

KW - amnesia

KW - animal experiment

KW - animal model

KW - animal tissue

KW - Article

KW - behavior disorder

KW - black-white box test

KW - calcium signaling

KW - cholestasis

KW - Cistus

KW - cognitive defect

KW - controlled study

KW - elevated plus maze test

KW - experimental behavioral test

KW - experimental memory impairment

KW - experimental steatohepatitis

KW - fibrosis

KW - freezing

KW - grooming

KW - histology

KW - human

KW - lipid diet

KW - liver cell

KW - liver tissue

KW - locomotion

KW - male

KW - memory assessment

KW - mouse

KW - necrosis

KW - neurotransmission

KW - nonalcoholic steatohepatitis

KW - nonhuman

KW - novel object recognition test

KW - open field test

KW - rearing

KW - rose

KW - scoring system

KW - sedation

KW - spatial memory test

KW - staining

KW - velocity

KW - young adult

UR - https://www.mendeley.com/catalogue/28a67d9f-8af5-34be-8a1d-6fbe31526406/

U2 - 10.31146/1682-8658-ecg-224-4-54-63

DO - 10.31146/1682-8658-ecg-224-4-54-63

M3 - статья

SP - 54

EP - 63

JO - Experimental and Clinical Gastroenterology

JF - Experimental and Clinical Gastroenterology

SN - 1682-8658

IS - 4

ER -