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Neural population dynamics reveals disruption of spinal circuits’ responses to proprioceptive input during electrical stimulation of sensory afferents. / Katic Secerovic, Natalija; Balaguer, Josep-Maria; Gorskii, Oleg; Pavlova, Natalia; Liang, Lucy; Ho, Jonathan; Grigsby, Erinn; Gerszten, Peter C.; Karal-ogly, Dzhina; Bulgin, Dmitry; Orlov, Sergei; Pirondini, Elvira; Musienko, Pavel; Raspopovic, Stanisa; Capogrosso, Marco.

In: Cell Reports, Vol. 43, No. 2, 113695, 27.02.2024.

Research output: Contribution to journal › Article › peer-review

Harvard

Katic Secerovic, N, Balaguer, J-M, Gorskii, O, Pavlova, N, Liang, L, Ho, J, Grigsby, E, Gerszten, PC, Karal-ogly, D, Bulgin, D, Orlov, S, Pirondini, E, Musienko, P, Raspopovic, S & Capogrosso, M 2024, 'Neural population dynamics reveals disruption of spinal circuits’ responses to proprioceptive input during electrical stimulation of sensory afferents', Cell Reports, vol. 43, no. 2, 113695. https://doi.org/10.1016/j.celrep.2024.113695, https://doi.org/10.1016/j.celrep.2024.113695

APA

Katic Secerovic, N., Balaguer, J-M., Gorskii, O., Pavlova, N., Liang, L., Ho, J., Grigsby, E., Gerszten, P. C., Karal-ogly, D., Bulgin, D., Orlov, S., Pirondini, E., Musienko, P., Raspopovic, S., & Capogrosso, M. (2024). Neural population dynamics reveals disruption of spinal circuits’ responses to proprioceptive input during electrical stimulation of sensory afferents. Cell Reports, 43(2), [113695]. https://doi.org/10.1016/j.celrep.2024.113695, https://doi.org/10.1016/j.celrep.2024.113695

Vancouver

Katic Secerovic N, Balaguer J-M, Gorskii O, Pavlova N, Liang L, Ho J et al. Neural population dynamics reveals disruption of spinal circuits’ responses to proprioceptive input during electrical stimulation of sensory afferents. Cell Reports. 2024 Feb 27;43(2). 113695. https://doi.org/10.1016/j.celrep.2024.113695, https://doi.org/10.1016/j.celrep.2024.113695

Author

Katic Secerovic, Natalija ; Balaguer, Josep-Maria ; Gorskii, Oleg ; Pavlova, Natalia ; Liang, Lucy ; Ho, Jonathan ; Grigsby, Erinn ; Gerszten, Peter C. ; Karal-ogly, Dzhina ; Bulgin, Dmitry ; Orlov, Sergei ; Pirondini, Elvira ; Musienko, Pavel ; Raspopovic, Stanisa ; Capogrosso, Marco. / Neural population dynamics reveals disruption of spinal circuits’ responses to proprioceptive input during electrical stimulation of sensory afferents. In: Cell Reports. 2024 ; Vol. 43, No. 2.

BibTeX

@article{0587b9ef4d034dd894b66e29c7b52c32,
title = "Neural population dynamics reveals disruption of spinal circuits{\textquoteright} responses to proprioceptive input during electrical stimulation of sensory afferents",
abstract = "While neurostimulation technologies are rapidly approaching clinical applications for sensorimotor disorders, the impact of electrical stimulation on network dynamics is still unknown. Given the high degree of shared processing in neural structures, it is critical to understand if neurostimulation affects functions that are related to, but not targeted by, the intervention. Here, we approach this question by studying the effects of electrical stimulation of cutaneous afferents on unrelated processing of proprioceptive inputs. We recorded intraspinal neural activity in four monkeys while generating proprioceptive inputs from the radial nerve. We then applied continuous stimulation to the radial nerve cutaneous branch and quantified the impact of the stimulation on spinal processing of proprioceptive inputs via neural population dynamics. Proprioceptive pulses consistently produce neural trajectories that are disrupted by concurrent cutaneous stimulation. This disruption propagates to the somatosensory cortex, suggesting that electrical stimulation can perturb natural information processing across the neural axis.",
keywords = "Electric Stimulation, Peripheral Nerves, Skin/innervation, Spine, electrical stimulation, spinal sensorimotor computations, neural population dynamics, CP: Neuroscience, manifold, somatosensory cortex, spinal cord",
author = "{Katic Secerovic}, Natalija and Josep-Maria Balaguer and Oleg Gorskii and Natalia Pavlova and Lucy Liang and Jonathan Ho and Erinn Grigsby and Gerszten, {Peter C.} and Dzhina Karal-ogly and Dmitry Bulgin and Sergei Orlov and Elvira Pirondini and Pavel Musienko and Stanisa Raspopovic and Marco Capogrosso",
year = "2024",
month = feb,
day = "27",
doi = "https://doi.org/10.1016/j.celrep.2024.113695",
language = "English",
volume = "43",
journal = "Cell Reports",
issn = "2639-1856",
publisher = "Cell Press",
number = "2",

}

RIS

TY - JOUR

T1 - Neural population dynamics reveals disruption of spinal circuits’ responses to proprioceptive input during electrical stimulation of sensory afferents

AU - Katic Secerovic, Natalija

AU - Balaguer, Josep-Maria

AU - Gorskii, Oleg

AU - Pavlova, Natalia

AU - Liang, Lucy

AU - Ho, Jonathan

AU - Grigsby, Erinn

AU - Gerszten, Peter C.

AU - Karal-ogly, Dzhina

AU - Bulgin, Dmitry

AU - Orlov, Sergei

AU - Pirondini, Elvira

AU - Musienko, Pavel

AU - Raspopovic, Stanisa

AU - Capogrosso, Marco

PY - 2024/2/27

Y1 - 2024/2/27

N2 - While neurostimulation technologies are rapidly approaching clinical applications for sensorimotor disorders, the impact of electrical stimulation on network dynamics is still unknown. Given the high degree of shared processing in neural structures, it is critical to understand if neurostimulation affects functions that are related to, but not targeted by, the intervention. Here, we approach this question by studying the effects of electrical stimulation of cutaneous afferents on unrelated processing of proprioceptive inputs. We recorded intraspinal neural activity in four monkeys while generating proprioceptive inputs from the radial nerve. We then applied continuous stimulation to the radial nerve cutaneous branch and quantified the impact of the stimulation on spinal processing of proprioceptive inputs via neural population dynamics. Proprioceptive pulses consistently produce neural trajectories that are disrupted by concurrent cutaneous stimulation. This disruption propagates to the somatosensory cortex, suggesting that electrical stimulation can perturb natural information processing across the neural axis.

AB - While neurostimulation technologies are rapidly approaching clinical applications for sensorimotor disorders, the impact of electrical stimulation on network dynamics is still unknown. Given the high degree of shared processing in neural structures, it is critical to understand if neurostimulation affects functions that are related to, but not targeted by, the intervention. Here, we approach this question by studying the effects of electrical stimulation of cutaneous afferents on unrelated processing of proprioceptive inputs. We recorded intraspinal neural activity in four monkeys while generating proprioceptive inputs from the radial nerve. We then applied continuous stimulation to the radial nerve cutaneous branch and quantified the impact of the stimulation on spinal processing of proprioceptive inputs via neural population dynamics. Proprioceptive pulses consistently produce neural trajectories that are disrupted by concurrent cutaneous stimulation. This disruption propagates to the somatosensory cortex, suggesting that electrical stimulation can perturb natural information processing across the neural axis.

KW - Electric Stimulation

KW - Peripheral Nerves

KW - Skin/innervation

KW - Spine

KW - electrical stimulation

KW - spinal sensorimotor computations

KW - neural population dynamics

KW - CP: Neuroscience

KW - manifold

KW - somatosensory cortex

KW - spinal cord

UR - https://www.mendeley.com/catalogue/287e78f0-a44e-34fb-abd8-63e145b9607e/

U2 - https://doi.org/10.1016/j.celrep.2024.113695

DO - https://doi.org/10.1016/j.celrep.2024.113695

M3 - Article

C2 - 38245870

VL - 43

JO - Cell Reports

JF - Cell Reports

SN - 2639-1856

IS - 2

M1 - 113695

ER -

ID: 120791668