TY - JOUR

T1 - Negative parenting modulates the association between mother’s DNA methylation profiles and adult offspring depression

AU - Hein, Sascha

AU - Thomas, Tina

AU - Yu. Naumova, Oxana

AU - Luthar, Suniya S.

AU - Grigorenko, Elena L.

PY - 2019/3

Y1 - 2019/3

N2 - This study aimed to examine whether the relationship between mothers’ DNA methylation profiles and offspring's depression is modulated by negative parenting. The participants were 35 African-American mother–offspring dyads. Young adult offspring (19 females; age = 17–29.5 years) were assessed on depressive symptoms, and mothers (36–51 years) were assessed on negative parenting. Methyl-binding domain (MBD) sequencing was used to assay genome-wide DNA methylation in peripheral T lymphocytes. Controlling for the effect of offspring's DNA methylation, mothers' DNA methylation was positively associated with offspring's depression. Hypermethylation of a subset of the epigenetic markers was associated with increased negative parenting. Negative parenting was positively correlated with offspring's depression as well, suggesting that negative parenting may be a modulator between the mother's epigenome and offspring's depression. This study is one of the first investigations of the modulating role of parenting behavior in associations between the mother's epigenome and offspring's depression.

AB - This study aimed to examine whether the relationship between mothers’ DNA methylation profiles and offspring's depression is modulated by negative parenting. The participants were 35 African-American mother–offspring dyads. Young adult offspring (19 females; age = 17–29.5 years) were assessed on depressive symptoms, and mothers (36–51 years) were assessed on negative parenting. Methyl-binding domain (MBD) sequencing was used to assay genome-wide DNA methylation in peripheral T lymphocytes. Controlling for the effect of offspring's DNA methylation, mothers' DNA methylation was positively associated with offspring's depression. Hypermethylation of a subset of the epigenetic markers was associated with increased negative parenting. Negative parenting was positively correlated with offspring's depression as well, suggesting that negative parenting may be a modulator between the mother's epigenome and offspring's depression. This study is one of the first investigations of the modulating role of parenting behavior in associations between the mother's epigenome and offspring's depression.

KW - depression

KW - DNA methylation

KW - emerging adulthood

KW - epigenome-wide association study

UR - http://www.scopus.com/inward/record.url?scp=85057034584&partnerID=8YFLogxK

U2 - 10.1002/dev.21789

DO - 10.1002/dev.21789

M3 - Article

C2 - 30471082

AN - SCOPUS:85057034584

VL - 61

SP - 304

EP - 310

JO - Developmental Psychobiology

JF - Developmental Psychobiology

SN - 0012-1630

IS - 2

ER -