Research output: Contribution to journal › Article › peer-review
N-Boc-α-diazo glutarimide as efficient reagent for assembling N-heterocycle-glutarimide diads via Rh(II)-catalyzed N–H insertion reaction. / Кантин, Григорий Павлович; Голубев, Павел Романович; Сапегин, Александр Владимирович; Бунев, Александр Сиясатович; Дарьин, Дмитрий Викторович.
In: Beilstein Journal of Organic Chemistry, Vol. 19, No. 19, 07.12.2023, p. 1841–1848.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - N-Boc-α-diazo glutarimide as efficient reagent for assembling N-heterocycle-glutarimide diads via Rh(II)-catalyzed N–H insertion reaction
AU - Кантин, Григорий Павлович
AU - Голубев, Павел Романович
AU - Сапегин, Александр Владимирович
AU - Бунев, Александр Сиясатович
AU - Дарьин, Дмитрий Викторович
PY - 2023/12/7
Y1 - 2023/12/7
N2 - A technique has been proposed for incorporating a heterocyclic component into a glutarimide framework employing a Rh 2(esp) 2-catalyzed N-H insertion with the involvement of N-Boc-α-diazo glutarimide. The new diazo reagent is more stable, soluble and convenient to prepare than the previously suggested one. The approach permits the application of diverse heterocycles, including both aromatic and saturated NH-substrates. This yields structures that are appealing for generating cereblon ubiquitin-ligase ligands and for potential use in crafting PROTAC molecules.
AB - A technique has been proposed for incorporating a heterocyclic component into a glutarimide framework employing a Rh 2(esp) 2-catalyzed N-H insertion with the involvement of N-Boc-α-diazo glutarimide. The new diazo reagent is more stable, soluble and convenient to prepare than the previously suggested one. The approach permits the application of diverse heterocycles, including both aromatic and saturated NH-substrates. This yields structures that are appealing for generating cereblon ubiquitin-ligase ligands and for potential use in crafting PROTAC molecules.
U2 - 10.3762/bjoc.19.136
DO - 10.3762/bjoc.19.136
M3 - Article
C2 - 38090627
VL - 19
SP - 1841
EP - 1848
JO - Beilstein Journal of Organic Chemistry
JF - Beilstein Journal of Organic Chemistry
SN - 1860-5397
IS - 19
ER -
ID: 114716030