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N-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of 68Ga- and Al18F-Labeled Radiopharmaceuticals. / Kondratenko, Yulia A.; Shilova, Julia S.; Gavrilov, Vladislav A.; Zolotarev, Andrey A.; Nadporojskii, Michail A.; Kochina, Tatyana A.; Antuganov, Dmitrii O.

In: Pharmaceutics, Vol. 15, No. 2, 694, 18.02.2023.

Research output: Contribution to journal › Article › peer-review

Harvard

Kondratenko, YA, Shilova, JS, Gavrilov, VA, Zolotarev, AA, Nadporojskii, MA, Kochina, TA & Antuganov, DO 2023, 'N-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of 68Ga- and Al18F-Labeled Radiopharmaceuticals', Pharmaceutics, vol. 15, no. 2, 694. https://doi.org/10.3390/pharmaceutics15020694

APA

Kondratenko, Y. A., Shilova, J. S., Gavrilov, V. A., Zolotarev, A. A., Nadporojskii, M. A., Kochina, T. A., & Antuganov, D. O. (2023). N-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of 68Ga- and Al18F-Labeled Radiopharmaceuticals. Pharmaceutics, 15(2), [694]. https://doi.org/10.3390/pharmaceutics15020694

Vancouver

Kondratenko YA, Shilova JS, Gavrilov VA, Zolotarev AA, Nadporojskii MA, Kochina TA et al. N-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of 68Ga- and Al18F-Labeled Radiopharmaceuticals. Pharmaceutics. 2023 Feb 18;15(2). 694. https://doi.org/10.3390/pharmaceutics15020694

Author

Kondratenko, Yulia A. ; Shilova, Julia S. ; Gavrilov, Vladislav A. ; Zolotarev, Andrey A. ; Nadporojskii, Michail A. ; Kochina, Tatyana A. ; Antuganov, Dmitrii O. / N-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of 68Ga- and Al18F-Labeled Radiopharmaceuticals. In: Pharmaceutics. 2023 ; Vol. 15, No. 2.

BibTeX

@article{94cdc1cc2b3c45d18dd3e271212310c2,
title = "N-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of 68Ga- and Al18F-Labeled Radiopharmaceuticals",
abstract = "Ionic liquids (ILs), due to their structural features, have unique physical and chemical properties and are environmentally friendly. Every year, the number of studies devoted to the use of ILs in medicine and pharmaceutics is growing. In nuclear medicine, the use of ILs with self-buffering capacity in the synthesis of radiopharmaceuticals is extremely important. This research is devoted to obtaining new ionic buffer agents containing N-benzylethanolammonium (BEA) cations and anions of carboxylic acids. A series of new BEA salts was synthesized and identified by NMR (1H, 13C), IR spectroscopy and elemental and thermal analysis. The crystal structures of BEA hydrogen succinate, hydrogen oxalate and oxalate were determined by x-ray diffraction. Newly synthesized compounds were tested as buffer solutions in 68Ga- and Al18F-radiolabeling reactions with a series of bifunctional chelating agents and clinically relevant peptides used for visualization of malignancies by positron emission tomography. The results obtained confirm the promise of using new buffers in the synthesis of 68Ga- and Al18F-labeled radiopharmaceuticals.",
keywords = "Good{\textquoteright}s buffer ionic liquids, N-benzylethanolamine, alkanolammonium salts, radiopharmaceuticals, nuclear medicine, PET",
author = "Kondratenko, {Yulia A.} and Shilova, {Julia S.} and Gavrilov, {Vladislav A.} and Zolotarev, {Andrey A.} and Nadporojskii, {Michail A.} and Kochina, {Tatyana A.} and Antuganov, {Dmitrii O.}",
note = "Kondratenko, Y.A.; Shilova, J.S.; Gavrilov, V.A.; Zolotarev, A.A.; Nadporojskii, M.A.; Kochina, T.A.; Antuganov, D.O. N-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of 68Ga- and Al18F-Labeled Radiopharmaceuticals. Pharmaceutics 2023, 15, 694. https://doi.org/10.3390/pharmaceutics15020694",
year = "2023",
month = feb,
day = "18",
doi = "10.3390/pharmaceutics15020694",
language = "English",
volume = "15",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "MDPI AG",
number = "2",

}

RIS

TY - JOUR

T1 - N-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of 68Ga- and Al18F-Labeled Radiopharmaceuticals

AU - Kondratenko, Yulia A.

AU - Shilova, Julia S.

AU - Gavrilov, Vladislav A.

AU - Zolotarev, Andrey A.

AU - Nadporojskii, Michail A.

AU - Kochina, Tatyana A.

AU - Antuganov, Dmitrii O.

N1 - Kondratenko, Y.A.; Shilova, J.S.; Gavrilov, V.A.; Zolotarev, A.A.; Nadporojskii, M.A.; Kochina, T.A.; Antuganov, D.O. N-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of 68Ga- and Al18F-Labeled Radiopharmaceuticals. Pharmaceutics 2023, 15, 694. https://doi.org/10.3390/pharmaceutics15020694

PY - 2023/2/18

Y1 - 2023/2/18

N2 - Ionic liquids (ILs), due to their structural features, have unique physical and chemical properties and are environmentally friendly. Every year, the number of studies devoted to the use of ILs in medicine and pharmaceutics is growing. In nuclear medicine, the use of ILs with self-buffering capacity in the synthesis of radiopharmaceuticals is extremely important. This research is devoted to obtaining new ionic buffer agents containing N-benzylethanolammonium (BEA) cations and anions of carboxylic acids. A series of new BEA salts was synthesized and identified by NMR (1H, 13C), IR spectroscopy and elemental and thermal analysis. The crystal structures of BEA hydrogen succinate, hydrogen oxalate and oxalate were determined by x-ray diffraction. Newly synthesized compounds were tested as buffer solutions in 68Ga- and Al18F-radiolabeling reactions with a series of bifunctional chelating agents and clinically relevant peptides used for visualization of malignancies by positron emission tomography. The results obtained confirm the promise of using new buffers in the synthesis of 68Ga- and Al18F-labeled radiopharmaceuticals.

AB - Ionic liquids (ILs), due to their structural features, have unique physical and chemical properties and are environmentally friendly. Every year, the number of studies devoted to the use of ILs in medicine and pharmaceutics is growing. In nuclear medicine, the use of ILs with self-buffering capacity in the synthesis of radiopharmaceuticals is extremely important. This research is devoted to obtaining new ionic buffer agents containing N-benzylethanolammonium (BEA) cations and anions of carboxylic acids. A series of new BEA salts was synthesized and identified by NMR (1H, 13C), IR spectroscopy and elemental and thermal analysis. The crystal structures of BEA hydrogen succinate, hydrogen oxalate and oxalate were determined by x-ray diffraction. Newly synthesized compounds were tested as buffer solutions in 68Ga- and Al18F-radiolabeling reactions with a series of bifunctional chelating agents and clinically relevant peptides used for visualization of malignancies by positron emission tomography. The results obtained confirm the promise of using new buffers in the synthesis of 68Ga- and Al18F-labeled radiopharmaceuticals.

KW - Good’s buffer ionic liquids

KW - N-benzylethanolamine

KW - alkanolammonium salts

KW - radiopharmaceuticals

KW - nuclear medicine

KW - PET

UR - https://www.mendeley.com/catalogue/e3700cfa-b235-3e02-bd3c-449916a3a0a0/

U2 - 10.3390/pharmaceutics15020694

DO - 10.3390/pharmaceutics15020694

M3 - Article

C2 - 36840016

VL - 15

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

IS - 2

M1 - 694

ER -

ID: 105240973