TY - CHAP

T1 - Nanogels Capable of Triggered Release

AU - Коржиков-Влах, Виктор Александрович

AU - Тенникова, Татьяна Борисовна

N1 - Publisher Copyright: © 2021, Springer Nature Switzerland AG.

PY - 2021/3/5

Y1 - 2021/3/5

N2 - This chapter provides an overview of soft and environmentally sensitivepolymeric nanosystems, which are widely known as nanogels. These particles keep great promise to the area of drug delivery due to their high biocompatibility with body fluids and tissues, as well as due to their ability to encapsulate and release the loaded drugs in a controlled manner. For a long period of time, the controlled drug delivery systems were designed to provide long-termed or sustained release. However, some medical treatments such as cancer chemotherapy, protein and gene delivery do not require the prolonged release of the drug in the site of action. In contrast, the rapid increase of the drug concentration is needed for gaining the desired biological effect. Being very sensitive to surrounding media and different stimuli, nanogels can undergo physico-chemical transitions or chemical changes in their structure. Such changes can result in more rapid release of the drugs, which is usually referred to as triggered drug release. Herein we give the basic information on nanogel unique features, methods of sensitive nanogels preparation, as well as onmain mechanisms of triggered release. Additionally, the triggered release oflow-molecular drugs and biomacromolecules are discussed.

AB - This chapter provides an overview of soft and environmentally sensitivepolymeric nanosystems, which are widely known as nanogels. These particles keep great promise to the area of drug delivery due to their high biocompatibility with body fluids and tissues, as well as due to their ability to encapsulate and release the loaded drugs in a controlled manner. For a long period of time, the controlled drug delivery systems were designed to provide long-termed or sustained release. However, some medical treatments such as cancer chemotherapy, protein and gene delivery do not require the prolonged release of the drug in the site of action. In contrast, the rapid increase of the drug concentration is needed for gaining the desired biological effect. Being very sensitive to surrounding media and different stimuli, nanogels can undergo physico-chemical transitions or chemical changes in their structure. Such changes can result in more rapid release of the drugs, which is usually referred to as triggered drug release. Herein we give the basic information on nanogel unique features, methods of sensitive nanogels preparation, as well as onmain mechanisms of triggered release. Additionally, the triggered release oflow-molecular drugs and biomacromolecules are discussed.

KW - системы доставки генетических лекарств

KW - наногели

KW - высвобождение лекарств

KW - резкое высвобождение

KW - Biopharmaceutics

KW - Nanogels

KW - Sensitivity

KW - Triggered release

KW - NEAR-INFRARED LIGHT

KW - ONE-POT SYNTHESIS

KW - CORE-SHELL NANOGELS

KW - CROSS-LINKING

KW - RESPONSIVE NANOGELS

KW - OLIGO(ETHYLENE GLYCOL)

KW - CRITICAL-SOLUTION TEMPERATURE

KW - HYALURONIC-ACID NANOGELS

KW - COPOLYMER MICELLES

KW - DRUG-DELIVERY SYSTEMS

UR - http://www.scopus.com/inward/record.url?scp=85106512321&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/76fc9891-b534-39d1-b9bf-1035cb820fef/

U2 - 10.1007/10_2021_163

DO - 10.1007/10_2021_163

M3 - Chapter

SN - 978-3-030-76768-6

T3 - Advances in Biochemical Engineering/Biotechnology

SP - 99

EP - 146

BT - Tunable Hydrogels: Smart Materials for Biomedical Applications

A2 - Lavrentieva, A

A2 - Pepelanova, null

A2 - Seliktar, D

PB - Springer Nature

CY - Berlin, Heidelberg

ER -