Nanocrystalline β-Ti alloy with high hardness, low Young's modulus and excellent in vitro biocompatibility for biomedical applications. / Xie, Kelvin Y.; Wang, Yanbo; Zhao, Yonghao; Chang, Li; Wang, Guocheng; Chen, Zibin; Cao, Yang; Liao, Xiaozhou; Lavernia, Enrique J.; Valiev, Ruslan Z.; Sarrafpour, Babak; Zoellner, Hans; Ringer, Simon P.
In: Materials Science and Engineering C, Vol. 33, No. 6, 01.08.2013, p. 3530-3536.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Nanocrystalline β-Ti alloy with high hardness, low Young's modulus and excellent in vitro biocompatibility for biomedical applications
AU - Xie, Kelvin Y.
AU - Wang, Yanbo
AU - Zhao, Yonghao
AU - Chang, Li
AU - Wang, Guocheng
AU - Chen, Zibin
AU - Cao, Yang
AU - Liao, Xiaozhou
AU - Lavernia, Enrique J.
AU - Valiev, Ruslan Z.
AU - Sarrafpour, Babak
AU - Zoellner, Hans
AU - Ringer, Simon P.
PY - 2013/8/1
Y1 - 2013/8/1
N2 - High strength, low Young's modulus and good biocompatibility are desirable but difficult to simultaneously achieve in metallic implant materials for load bearing applications, and these impose significant challenges in material design. Here we report that a nano-grained β-Ti alloy prepared by high-pressure torsion exhibits remarkable mechanical and biological properties. The hardness and modulus of the nano-grained Ti alloy were respectively 23% higher and 34% lower than those of its coarse-grained counterpart. Fibroblast cell attachment and proliferation were enhanced, demonstrating good in vitro biocompatibility of the nano-grained Ti alloy, consistent with demonstrated increased nano-roughness on the nano-grained Ti alloy. Results suggest that the nano-grained β-Ti alloy may have significant application as an implant material in dental and orthopedic applications.
AB - High strength, low Young's modulus and good biocompatibility are desirable but difficult to simultaneously achieve in metallic implant materials for load bearing applications, and these impose significant challenges in material design. Here we report that a nano-grained β-Ti alloy prepared by high-pressure torsion exhibits remarkable mechanical and biological properties. The hardness and modulus of the nano-grained Ti alloy were respectively 23% higher and 34% lower than those of its coarse-grained counterpart. Fibroblast cell attachment and proliferation were enhanced, demonstrating good in vitro biocompatibility of the nano-grained Ti alloy, consistent with demonstrated increased nano-roughness on the nano-grained Ti alloy. Results suggest that the nano-grained β-Ti alloy may have significant application as an implant material in dental and orthopedic applications.
KW - Cell attachment and proliferation
KW - High-pressure torsion
KW - Mechanical properties
KW - Ti alloy
UR - http://www.scopus.com/inward/record.url?scp=84878221506&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2013.04.044
DO - 10.1016/j.msec.2013.04.044
M3 - Article
C2 - 23706243
AN - SCOPUS:84878221506
VL - 33
SP - 3530
EP - 3536
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
SN - 0928-4931
IS - 6
ER -
ID: 35165117