The intensity of mesoscale wind speed variations with periods 1.7 – 5.6 hr was determined by digital filtering of the measurements at mesosphere and lower thermosphere region, which had been performed at the Collm Observatory of Leipzig University (51.3° N, 13.0° E) using the ionospheric drift method in the years 1983 – 2007 and with a meteor radar in 2004 – 2018. This made it possible to obtain the continuous series of measurements for the interval of 1983 - 2018. Interannual changes at 88 km altitude are studied. The annual mean zonal wind was directed to the east in 1983 – 2018 and grew from 3 to 10 m/s. The meridional southward wind reached a minimum of 2 m/s around 2002 and a maximum of 10 m/s in 2012. The intensity of mesoscale waves varied within the limits of up to 10%.