A reliable and convenient protocol for MCRs between 2-aminopyrimidine, aldehydes and isonitriles is described. Toluene was chosen as the reaction solvent based on mechanistic reasoning. The product mixtures were found to contain a single imidazo[1,2-a]pyrimidine product in each case, which were isolated and purified by precipitation and crystallization. Chromatographic recovery from filtrates raised the total yields to 49-66%. The procedure provides a practical alternative to hitherto reported methods in which formation of multiple products was observed.
| Original language | English |
|---|---|
| Pages (from-to) | 947-951 |
| Number of pages | 5 |
| Journal | Tetrahedron Letters |
| Volume | 47 |
| Issue number | 6 |
| DOIs | |
| State | Published - 6 Feb 2006 |
| Externally published | Yes |
ID: 97905470