Mucormycosis in haematological patients : Case report and results of prospective study in Saint Petersburg, Russia. / Klimko, Nikolay N.; Khostelidi, Sofya N.; Volkova, Alisya G.; Popova, Marina O.; Bogomolova, Tatyana S.; Zuborovskaya, Ludmila S.; Kolbin, Aleksey S.; Medvedeva, Nadezhda V.; Zuzgin, Ilya S.; Simkin, Sergey M.; Vasilyeva, Nataliya V.; Afanasiev, Boris V.
In: Mycoses, Vol. 57, No. s3, 01.12.2014, p. 91-96.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Mucormycosis in haematological patients
T2 - Case report and results of prospective study in Saint Petersburg, Russia
AU - Klimko, Nikolay N.
AU - Khostelidi, Sofya N.
AU - Volkova, Alisya G.
AU - Popova, Marina O.
AU - Bogomolova, Tatyana S.
AU - Zuborovskaya, Ludmila S.
AU - Kolbin, Aleksey S.
AU - Medvedeva, Nadezhda V.
AU - Zuzgin, Ilya S.
AU - Simkin, Sergey M.
AU - Vasilyeva, Nataliya V.
AU - Afanasiev, Boris V.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - We prospectively observed 36 haematological patients with mucormycosis from nine hospitals of St. Petersburg during 2004-2013. The most frequent underlying diseases were acute leukaemia (64%), and main risk factors were prolonged neutropenia (92%) and lymphocytopenia (86%). In 50% of the patients, mucormycosis was diagnosed 1-65 days after invasive aspergillosis. Main clinical form of mucormycosis was pulmonary (64%), while two or more organ involvement was noted in 50% of the cases. The most frequent aetiological agents of mucormycosis were Rhizopus spp. (48%). Twelve-week survival rate was 50%. Combination therapy (echinocandins + amphotericin B forms) and recovery from the underlying disease significantly improved the survival rate.
AB - We prospectively observed 36 haematological patients with mucormycosis from nine hospitals of St. Petersburg during 2004-2013. The most frequent underlying diseases were acute leukaemia (64%), and main risk factors were prolonged neutropenia (92%) and lymphocytopenia (86%). In 50% of the patients, mucormycosis was diagnosed 1-65 days after invasive aspergillosis. Main clinical form of mucormycosis was pulmonary (64%), while two or more organ involvement was noted in 50% of the cases. The most frequent aetiological agents of mucormycosis were Rhizopus spp. (48%). Twelve-week survival rate was 50%. Combination therapy (echinocandins + amphotericin B forms) and recovery from the underlying disease significantly improved the survival rate.
KW - Acute leukaemia
KW - Haematological malignancy
KW - Lichtheimia corymbifera
KW - Mucormycosis
KW - Pulmonary mucormycosis
KW - Skin and soft tissue
UR - http://www.scopus.com/inward/record.url?scp=85027958296&partnerID=8YFLogxK
U2 - 10.1111/myc.12247
DO - 10.1111/myc.12247
M3 - Article
AN - SCOPUS:85027958296
VL - 57
SP - 91
EP - 96
JO - Mycoses
JF - Mycoses
SN - 0933-7407
IS - s3
ER -
ID: 42978552