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MPTP-Treated Zebrafish Recapitulate ‘Late-Stage’ Parkinson’s-like Cognitive Decline. / Bashirzade, Alim A. O.; Cheresiz, Sergey V.; Belova, Alisa S.; Drobkov, Alexey V.; Korotaeva, Anastasiia D.; Azizi-arani, Soheil; Azimirad, Amirhossein; Odle, Eric; Gild, Emma-yanina V.; Ardashov, Oleg V.; Volcho, Konstantin P.; Bozhko, Dmitrii V.; Myrov, Vladislav O.; Kolchanova, Sofia M.; Polovian, Aleksander I.; Galumov, Georgii K.; Salakhutdinov, Nariman F.; Amstislavskaya, Tamara G.; Kalueff, Allan V.

In: Toxics, Vol. 10, No. 2, 69, 04.02.2022.

Research output: Contribution to journal › Article › peer-review

Harvard

Bashirzade, AAO, Cheresiz, SV, Belova, AS, Drobkov, AV, Korotaeva, AD, Azizi-arani, S, Azimirad, A, Odle, E, Gild, EV, Ardashov, OV, Volcho, KP, Bozhko, DV, Myrov, VO, Kolchanova, SM, Polovian, AI, Galumov, GK, Salakhutdinov, NF, Amstislavskaya, TG & Kalueff, AV 2022, 'MPTP-Treated Zebrafish Recapitulate ‘Late-Stage’ Parkinson’s-like Cognitive Decline', Toxics, vol. 10, no. 2, 69. https://doi.org/10.3390/toxics10020069

APA

Bashirzade, A. A. O., Cheresiz, S. V., Belova, A. S., Drobkov, A. V., Korotaeva, A. D., Azizi-arani, S., Azimirad, A., Odle, E., Gild, E. V., Ardashov, O. V., Volcho, K. P., Bozhko, D. V., Myrov, V. O., Kolchanova, S. M., Polovian, A. I., Galumov, G. K., Salakhutdinov, N. F., Amstislavskaya, T. G., & Kalueff, A. V. (2022). MPTP-Treated Zebrafish Recapitulate ‘Late-Stage’ Parkinson’s-like Cognitive Decline. Toxics, 10(2), [69]. https://doi.org/10.3390/toxics10020069

Vancouver

Bashirzade AAO, Cheresiz SV, Belova AS, Drobkov AV, Korotaeva AD, Azizi-arani S et al. MPTP-Treated Zebrafish Recapitulate ‘Late-Stage’ Parkinson’s-like Cognitive Decline. Toxics. 2022 Feb 4;10(2). 69. https://doi.org/10.3390/toxics10020069

Author

Bashirzade, Alim A. O. ; Cheresiz, Sergey V. ; Belova, Alisa S. ; Drobkov, Alexey V. ; Korotaeva, Anastasiia D. ; Azizi-arani, Soheil ; Azimirad, Amirhossein ; Odle, Eric ; Gild, Emma-yanina V. ; Ardashov, Oleg V. ; Volcho, Konstantin P. ; Bozhko, Dmitrii V. ; Myrov, Vladislav O. ; Kolchanova, Sofia M. ; Polovian, Aleksander I. ; Galumov, Georgii K. ; Salakhutdinov, Nariman F. ; Amstislavskaya, Tamara G. ; Kalueff, Allan V. / MPTP-Treated Zebrafish Recapitulate ‘Late-Stage’ Parkinson’s-like Cognitive Decline. In: Toxics. 2022 ; Vol. 10, No. 2.

BibTeX

@article{e8b20649d3a04911ab41b330b5bf9995,
title = "MPTP-Treated Zebrafish Recapitulate {\textquoteleft}Late-Stage{\textquoteright} Parkinson{\textquoteright}s-like Cognitive Decline",
abstract = "The zebrafish is a promising model species in biomedical research, including neurotoxicology and neuroactive drug screening. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) evokes degeneration of dopaminergic neurons and is commonly used to model Parkinson{\textquoteright}s disease (PD) in laboratory animals, including zebrafish. However, cognitive phenotypes in MPTP-evoked experimental PD models remain poorly understood. Here, we established an LD50 (292 mg/kg) for intraperitoneal MPTP administration in adult zebrafish, and report impaired spatial working memory (poorer spontaneous alternation in the Y-maze) in a PD model utilizing fish treated with 200 µg of this agent. In addition to conventional behavioral analyses, we also employed artificial intelligence (AI)-based approaches to independently and without bias characterize MPTP effects on zebrafish behavior during the Y-maze test. These analyses yielded a distinct cluster for 200-µg MPTP (vs. other) groups, suggesting that high-dose MPTP produced distinct, computationally detectable patterns of zebrafish swimming. Collectively, these findings support MPTP treatment in adult zebrafish as a late-stage experimental PD model with overt cognitive phenotypes.",
keywords = "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), Artificial intelligence, Inhibitory avoidance task, Parkinson{\textquoteright}s disease, Spontaneous alternation, Zebrafish, DANIO-RERIO, TASK, Parkinson's disease, LOW-DOSE MPTP, 6-tetrahydropyridine (MPTP), MECHANISMS, spontaneous alternation, MODEL, artificial intelligence, IMPAIRMENT, 2, inhibitory avoidance task, 3, DISEASE, zebrafish, DEFICITS, 1-Methyl-4-phenyl-1, WORKING-MEMORY",
author = "Bashirzade, {Alim A. O.} and Cheresiz, {Sergey V.} and Belova, {Alisa S.} and Drobkov, {Alexey V.} and Korotaeva, {Anastasiia D.} and Soheil Azizi-arani and Amirhossein Azimirad and Eric Odle and Gild, {Emma-yanina V.} and Ardashov, {Oleg V.} and Volcho, {Konstantin P.} and Bozhko, {Dmitrii V.} and Myrov, {Vladislav O.} and Kolchanova, {Sofia M.} and Polovian, {Aleksander I.} and Galumov, {Georgii K.} and Salakhutdinov, {Nariman F.} and Amstislavskaya, {Tamara G.} and Kalueff, {Allan V.}",
note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
month = feb,
day = "4",
doi = "10.3390/toxics10020069",
language = "English",
volume = "10",
journal = "Toxics",
issn = "2305-6304",
publisher = "MDPI AG",
number = "2",

}

RIS

TY - JOUR

T1 - MPTP-Treated Zebrafish Recapitulate ‘Late-Stage’ Parkinson’s-like Cognitive Decline

AU - Bashirzade, Alim A. O.

AU - Cheresiz, Sergey V.

AU - Belova, Alisa S.

AU - Drobkov, Alexey V.

AU - Korotaeva, Anastasiia D.

AU - Azizi-arani, Soheil

AU - Azimirad, Amirhossein

AU - Odle, Eric

AU - Gild, Emma-yanina V.

AU - Ardashov, Oleg V.

AU - Volcho, Konstantin P.

AU - Bozhko, Dmitrii V.

AU - Myrov, Vladislav O.

AU - Kolchanova, Sofia M.

AU - Polovian, Aleksander I.

AU - Galumov, Georgii K.

AU - Salakhutdinov, Nariman F.

AU - Amstislavskaya, Tamara G.

AU - Kalueff, Allan V.

N1 - Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/2/4

Y1 - 2022/2/4

N2 - The zebrafish is a promising model species in biomedical research, including neurotoxicology and neuroactive drug screening. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) evokes degeneration of dopaminergic neurons and is commonly used to model Parkinson’s disease (PD) in laboratory animals, including zebrafish. However, cognitive phenotypes in MPTP-evoked experimental PD models remain poorly understood. Here, we established an LD50 (292 mg/kg) for intraperitoneal MPTP administration in adult zebrafish, and report impaired spatial working memory (poorer spontaneous alternation in the Y-maze) in a PD model utilizing fish treated with 200 µg of this agent. In addition to conventional behavioral analyses, we also employed artificial intelligence (AI)-based approaches to independently and without bias characterize MPTP effects on zebrafish behavior during the Y-maze test. These analyses yielded a distinct cluster for 200-µg MPTP (vs. other) groups, suggesting that high-dose MPTP produced distinct, computationally detectable patterns of zebrafish swimming. Collectively, these findings support MPTP treatment in adult zebrafish as a late-stage experimental PD model with overt cognitive phenotypes.

AB - The zebrafish is a promising model species in biomedical research, including neurotoxicology and neuroactive drug screening. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) evokes degeneration of dopaminergic neurons and is commonly used to model Parkinson’s disease (PD) in laboratory animals, including zebrafish. However, cognitive phenotypes in MPTP-evoked experimental PD models remain poorly understood. Here, we established an LD50 (292 mg/kg) for intraperitoneal MPTP administration in adult zebrafish, and report impaired spatial working memory (poorer spontaneous alternation in the Y-maze) in a PD model utilizing fish treated with 200 µg of this agent. In addition to conventional behavioral analyses, we also employed artificial intelligence (AI)-based approaches to independently and without bias characterize MPTP effects on zebrafish behavior during the Y-maze test. These analyses yielded a distinct cluster for 200-µg MPTP (vs. other) groups, suggesting that high-dose MPTP produced distinct, computationally detectable patterns of zebrafish swimming. Collectively, these findings support MPTP treatment in adult zebrafish as a late-stage experimental PD model with overt cognitive phenotypes.

KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

KW - Artificial intelligence

KW - Inhibitory avoidance task

KW - Parkinson’s disease

KW - Spontaneous alternation

KW - Zebrafish

KW - DANIO-RERIO

KW - TASK

KW - Parkinson's disease

KW - LOW-DOSE MPTP

KW - 6-tetrahydropyridine (MPTP)

KW - MECHANISMS

KW - spontaneous alternation

KW - MODEL

KW - artificial intelligence

KW - IMPAIRMENT

KW - 2

KW - inhibitory avoidance task

KW - 3

KW - DISEASE

KW - zebrafish

KW - DEFICITS

KW - 1-Methyl-4-phenyl-1

KW - WORKING-MEMORY

UR - http://www.scopus.com/inward/record.url?scp=85124333068&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/23b3bbff-5822-3a34-b37f-6f884d9cd813/

U2 - 10.3390/toxics10020069

DO - 10.3390/toxics10020069

M3 - Article

C2 - 35202255

VL - 10

JO - Toxics

JF - Toxics

SN - 2305-6304

IS - 2

M1 - 69

ER -

ID: 92447815