TY - JOUR

T1 - Morfologicheskie osobennosti sochetaniya tuberkuleza i raka legkikh

AU - Novitskaya, T. A.

AU - Ariel, B. M.

AU - Dvorakovskaya, I. V.

AU - Avetisyan, A. O.

AU - Yablonsky, P. K.

N1 - Publisher Copyright: © 2021, Media Sphera Publishing Group. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021

Y1 - 2021

N2 - The pathogenetic relationship between pulmonary tuberculosis and lung cancer in their concurrence is now still the subject of discussion. Objective. To study the pathogenetic relationship between pulmonary tuberculosis and lung cancer. Material and methods. The investigators examined surgical material from 51 patients (41 men) aged 41—73 years (mean age, 63.7 years) with pulmonary tuberculosis concurrent with lung cancer. They also studied tumors, tuberculous caverns, infiltrates, and foci with surrounding macroscopically intact lung tissue, as well as fibrotic changes by histological, histochemical and immunohistochemical examinations. Results. Previous tuberculosis can be considered as a risk factor for lung cancer. Central cancer was more common in patients with inactive, chronic tuberculosis with a predominance of fibrotic processes in the root of the lung and in its hilar zones. Fibrous-cavernous tuberculosis and cavernous tuberculosis were more frequently concurrent with central cancer; peripheral tumors mainly occurred in infiltrative tuberculosis and tuberculomas. Conclusion. The findings suggest that in a number of cases, cancer and tuberculosis may be anatomically close, developing in the same anatomical unit — the lung. However, this does not indicate an unambiguous etiopathogenetic relationship between pulmonary tuberculosis and lung cancer. The relationships between pulmonary tuberculosis and lung cancer are much more complex and do not fit into the simple scheme of cause-and-effect relations.

AB - The pathogenetic relationship between pulmonary tuberculosis and lung cancer in their concurrence is now still the subject of discussion. Objective. To study the pathogenetic relationship between pulmonary tuberculosis and lung cancer. Material and methods. The investigators examined surgical material from 51 patients (41 men) aged 41—73 years (mean age, 63.7 years) with pulmonary tuberculosis concurrent with lung cancer. They also studied tumors, tuberculous caverns, infiltrates, and foci with surrounding macroscopically intact lung tissue, as well as fibrotic changes by histological, histochemical and immunohistochemical examinations. Results. Previous tuberculosis can be considered as a risk factor for lung cancer. Central cancer was more common in patients with inactive, chronic tuberculosis with a predominance of fibrotic processes in the root of the lung and in its hilar zones. Fibrous-cavernous tuberculosis and cavernous tuberculosis were more frequently concurrent with central cancer; peripheral tumors mainly occurred in infiltrative tuberculosis and tuberculomas. Conclusion. The findings suggest that in a number of cases, cancer and tuberculosis may be anatomically close, developing in the same anatomical unit — the lung. However, this does not indicate an unambiguous etiopathogenetic relationship between pulmonary tuberculosis and lung cancer. The relationships between pulmonary tuberculosis and lung cancer are much more complex and do not fit into the simple scheme of cause-and-effect relations.

KW - Cancer

KW - Lung

KW - Pathogenesis

KW - Tuberculosis

KW - Adult

KW - Aged

KW - Humans

KW - Lung

KW - Lung Neoplasms/complications

KW - Male

KW - Middle Aged

KW - Risk Factors

KW - Tuberculosis, Pulmonary/complications

UR - http://www.scopus.com/inward/record.url?scp=85103994633&partnerID=8YFLogxK

U2 - 10.17116/patol20218302119

DO - 10.17116/patol20218302119

M3 - статья

C2 - 33822550

AN - SCOPUS:85103994633

VL - 83

SP - 19

EP - 24

JO - АРХИВ ПАТОЛОГИИ

JF - АРХИВ ПАТОЛОГИИ

SN - 0004-1955

IS - 3

ER -