TY - JOUR

T1 - Monoclonal gammopathy of undetermined significance (MGUS) manifestation in CNS

T2 - A regular or chance occurrence?

AU - Prakhova, Lidiia

AU - Lebedev, Valeriy

AU - Ilves, Aleksandr

AU - Nazinkina, Yulia

N1 - Publisher Copyright: © BMJ Publishing Group Limited 2021.

PY - 2021/3/24

Y1 - 2021/3/24

N2 - Monoclonal gammopathy of undetermined significance (MGUS)-associated involvement of the peripheral nervous system is widely reported in the literature. At the same time, involvement of central nervous system (CNS) occurs far less frequently. Analysing the reported cases, almost all the authors pose the question whether there is a relationship between CNS involvement and MGUS, and at what stage it is necessary to begin therapy of haematological disorders. The limited number of reported cases precludes us from getting a definite answer to these questions, thus making further accumulation of clinical data highly relevant. In this article, we present two cases of CNS involvement in patients with MGUS, which, in our opinion, may suggest the existence of a causal relationship between MGUS and CNS involvement. Currently, the above hypothesis cannot be taken as proved due to the lack of a sufficient number of clinical observations and scientific studies. Therefore, the issue of MGUS-associated CNS involvement requires further research.

AB - Monoclonal gammopathy of undetermined significance (MGUS)-associated involvement of the peripheral nervous system is widely reported in the literature. At the same time, involvement of central nervous system (CNS) occurs far less frequently. Analysing the reported cases, almost all the authors pose the question whether there is a relationship between CNS involvement and MGUS, and at what stage it is necessary to begin therapy of haematological disorders. The limited number of reported cases precludes us from getting a definite answer to these questions, thus making further accumulation of clinical data highly relevant. In this article, we present two cases of CNS involvement in patients with MGUS, which, in our opinion, may suggest the existence of a causal relationship between MGUS and CNS involvement. Currently, the above hypothesis cannot be taken as proved due to the lack of a sufficient number of clinical observations and scientific studies. Therefore, the issue of MGUS-associated CNS involvement requires further research.

KW - central nervous system

KW - haematology (incl blood transfusion)

KW - monoclonal gammopathy of undetermined significance

KW - monoclonal gammopathy of undetermined significance associated neuropathy

KW - neurology

KW - Monoclonal Gammopathy of Undetermined Significance/complications

KW - Central Nervous System

KW - Humans

KW - Paraproteinemias

KW - Multiple Myeloma

KW - RENAL SIGNIFICANCE

UR - http://www.scopus.com/inward/record.url?scp=85103237688&partnerID=8YFLogxK

U2 - 10.1136/bcr-2020-237726

DO - 10.1136/bcr-2020-237726

M3 - Article

C2 - 33762271

AN - SCOPUS:85103237688

VL - 14

JO - BMJ Case Reports

JF - BMJ Case Reports

SN - 1757-790X

IS - 3

M1 - e237726

ER -