Molybdenum disulfide surface modification of ultrafine-grained titanium for enhanced cellular growth and antibacterial effect

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Molybdenum disulfide surface modification of ultrafine-grained titanium for enhanced cellular growth and antibacterial effect. / Shin, Myeong Hwan; Baek, Seung Mi; Polyakov, Alexander V.; Semenova, Irina P.; Valiev, Ruslan Z.; Hwang, Woon Bong; Hahn, Sei Kwang; Kim, Hyoung Seop.

In: Scientific Reports, Vol. 8, No. 1, 9907, 02.07.2018.

Research output: Contribution to journal › Article › peer-review

Author

Shin, Myeong Hwan ; Baek, Seung Mi ; Polyakov, Alexander V. ; Semenova, Irina P. ; Valiev, Ruslan Z. ; Hwang, Woon Bong ; Hahn, Sei Kwang ; Kim, Hyoung Seop. / Molybdenum disulfide surface modification of ultrafine-grained titanium for enhanced cellular growth and antibacterial effect. In: Scientific Reports. 2018 ; Vol. 8, No. 1.

BibTeX

@article{8ac35859b6ee48f09c241ca1b56cde62,

title = "Molybdenum disulfide surface modification of ultrafine-grained titanium for enhanced cellular growth and antibacterial effect",

abstract = "The commercially pure Ti (CP Ti) and equal-channel angular pressing (ECAP) processed Ti can contribute to the downsizing of medical devices with their superior mechanical properties and negligible toxicity. However, the ECAP-processed pure Ti has the risk of bacterial infection. Here, the coarse- and ultrafine-grained Ti substrates were surface-modified with molybdenum disulfide (MoS2) to improve the cell proliferation and growth with antibacterial effect for further dental applications. According to in vitro tests using the pre-osteoblast of MC3T3-E1 cell and a bacterial model of Escherichia coli (E. coli), MoS2 nanoflakes coated and ECAP-processed Ti substrates showed a significant increase in surface energy and singlet oxygen generation resulting in improved cell attachment and antibacterial effect. In addition, we confirmed the stability of the surface modified Ti substrates in a physiological solution and an artificial bone. Taken together, MoS2 modified and ECAP-processed Ti substrates might be successfully harnessed for various dental applications.",

keywords = "HIGH-PRESSURE TORSION, NANOSTRUCTURED TITANIUM, BIOMEDICAL APPLICATIONS, BACTERIAL ADHESION, PURE TITANIUM, OSTEOBLAST FUNCTIONS, AQUEOUS DISPERSIONS, MOS2, GRAPHENE, ALLOYS",

author = "Shin, {Myeong Hwan} and Baek, {Seung Mi} and Polyakov, {Alexander V.} and Semenova, {Irina P.} and Valiev, {Ruslan Z.} and Hwang, {Woon Bong} and Hahn, {Sei Kwang} and Kim, {Hyoung Seop}",

year = "2018",

month = jul,

day = "2",

doi = "10.1038/s41598-018-28367-0",

language = "English",

volume = "8",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

RIS

TY - JOUR

T1 - Molybdenum disulfide surface modification of ultrafine-grained titanium for enhanced cellular growth and antibacterial effect

AU - Shin, Myeong Hwan

AU - Baek, Seung Mi

AU - Polyakov, Alexander V.

AU - Semenova, Irina P.

AU - Valiev, Ruslan Z.

AU - Hwang, Woon Bong

AU - Hahn, Sei Kwang

AU - Kim, Hyoung Seop

PY - 2018/7/2

Y1 - 2018/7/2

N2 - The commercially pure Ti (CP Ti) and equal-channel angular pressing (ECAP) processed Ti can contribute to the downsizing of medical devices with their superior mechanical properties and negligible toxicity. However, the ECAP-processed pure Ti has the risk of bacterial infection. Here, the coarse- and ultrafine-grained Ti substrates were surface-modified with molybdenum disulfide (MoS2) to improve the cell proliferation and growth with antibacterial effect for further dental applications. According to in vitro tests using the pre-osteoblast of MC3T3-E1 cell and a bacterial model of Escherichia coli (E. coli), MoS2 nanoflakes coated and ECAP-processed Ti substrates showed a significant increase in surface energy and singlet oxygen generation resulting in improved cell attachment and antibacterial effect. In addition, we confirmed the stability of the surface modified Ti substrates in a physiological solution and an artificial bone. Taken together, MoS2 modified and ECAP-processed Ti substrates might be successfully harnessed for various dental applications.

AB - The commercially pure Ti (CP Ti) and equal-channel angular pressing (ECAP) processed Ti can contribute to the downsizing of medical devices with their superior mechanical properties and negligible toxicity. However, the ECAP-processed pure Ti has the risk of bacterial infection. Here, the coarse- and ultrafine-grained Ti substrates were surface-modified with molybdenum disulfide (MoS2) to improve the cell proliferation and growth with antibacterial effect for further dental applications. According to in vitro tests using the pre-osteoblast of MC3T3-E1 cell and a bacterial model of Escherichia coli (E. coli), MoS2 nanoflakes coated and ECAP-processed Ti substrates showed a significant increase in surface energy and singlet oxygen generation resulting in improved cell attachment and antibacterial effect. In addition, we confirmed the stability of the surface modified Ti substrates in a physiological solution and an artificial bone. Taken together, MoS2 modified and ECAP-processed Ti substrates might be successfully harnessed for various dental applications.

KW - HIGH-PRESSURE TORSION

KW - NANOSTRUCTURED TITANIUM

KW - BIOMEDICAL APPLICATIONS

KW - BACTERIAL ADHESION

KW - PURE TITANIUM

KW - OSTEOBLAST FUNCTIONS

KW - AQUEOUS DISPERSIONS

KW - MOS2

KW - GRAPHENE

KW - ALLOYS

UR - http://www.scopus.com/inward/record.url?scp=85049406168&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/molybdenum-disulfide-surface-modification-ultrafinegrained-titanium-enhanced-cellular-growth-antibac

U2 - 10.1038/s41598-018-28367-0

DO - 10.1038/s41598-018-28367-0

M3 - Article

AN - SCOPUS:85049406168

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 9907

ER -

ID: 35162138