Modeling of glycolytic wave propagation in an open spatial reactor with inhomogeneous substrate influx

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Modeling of glycolytic wave propagation in an open spatial reactor with inhomogeneous substrate influx. / Lavrova, A. I.; Bagyan, S.; Mair, T.; Hauser, M. J.B.; Schimansky-Geier, L.

In: BioSystems, Vol. 97, No. 2, 01.08.2009, p. 127-133.

Research output: Contribution to journal › Article › peer-review

Author

Lavrova, A. I. ; Bagyan, S. ; Mair, T. ; Hauser, M. J.B. ; Schimansky-Geier, L. / Modeling of glycolytic wave propagation in an open spatial reactor with inhomogeneous substrate influx. In: BioSystems. 2009 ; Vol. 97, No. 2. pp. 127-133.

BibTeX

@article{a6353f247e114cf79632364cc50c21ef,

title = "Modeling of glycolytic wave propagation in an open spatial reactor with inhomogeneous substrate influx",

abstract = "The spatio-temporal dynamics of traveling waves in glycolysis as it occurs in yeast extract have been studied, both theoretically and experimentally. We describe this phenomenon with the distributed Selkov model that accounts for the reactions of phosphofructokinase, which is a key enzyme of the glycolytic reaction cascade. To describe the experimentally observed phase waves in an open spatial reactor we introduce a non-homogeneous flux of substrate in the model. The experimental observation that waves can change their direction of propagation during the experiment is considered in the model. The mechanism for such a change in wave direction is discussed.",

keywords = "Glycolytic oscillations, Selkov model, Spatio-temporal dynamics",

author = "Lavrova, {A. I.} and S. Bagyan and T. Mair and Hauser, {M. J.B.} and L. Schimansky-Geier",

year = "2009",

month = aug,

day = "1",

doi = "10.1016/j.biosystems.2009.04.005",

language = "English",

volume = "97",

pages = "127--133",

journal = "BioSystems",

issn = "0303-2647",

publisher = "Elsevier",

number = "2",

}

RIS

TY - JOUR

T1 - Modeling of glycolytic wave propagation in an open spatial reactor with inhomogeneous substrate influx

AU - Lavrova, A. I.

AU - Bagyan, S.

AU - Mair, T.

AU - Hauser, M. J.B.

AU - Schimansky-Geier, L.

PY - 2009/8/1

Y1 - 2009/8/1

N2 - The spatio-temporal dynamics of traveling waves in glycolysis as it occurs in yeast extract have been studied, both theoretically and experimentally. We describe this phenomenon with the distributed Selkov model that accounts for the reactions of phosphofructokinase, which is a key enzyme of the glycolytic reaction cascade. To describe the experimentally observed phase waves in an open spatial reactor we introduce a non-homogeneous flux of substrate in the model. The experimental observation that waves can change their direction of propagation during the experiment is considered in the model. The mechanism for such a change in wave direction is discussed.

AB - The spatio-temporal dynamics of traveling waves in glycolysis as it occurs in yeast extract have been studied, both theoretically and experimentally. We describe this phenomenon with the distributed Selkov model that accounts for the reactions of phosphofructokinase, which is a key enzyme of the glycolytic reaction cascade. To describe the experimentally observed phase waves in an open spatial reactor we introduce a non-homogeneous flux of substrate in the model. The experimental observation that waves can change their direction of propagation during the experiment is considered in the model. The mechanism for such a change in wave direction is discussed.

KW - Glycolytic oscillations

KW - Selkov model

KW - Spatio-temporal dynamics

UR - http://www.scopus.com/inward/record.url?scp=67649494317&partnerID=8YFLogxK

U2 - 10.1016/j.biosystems.2009.04.005

DO - 10.1016/j.biosystems.2009.04.005

M3 - Article

C2 - 19409445

AN - SCOPUS:67649494317

VL - 97

SP - 127

EP - 133

JO - BioSystems

JF - BioSystems

SN - 0303-2647

IS - 2

ER -

ID: 27612728