Research output: Contribution to journal › Article › peer-review
Modeling disease dynamics and survivor functions by sanogenesis curves. / Bart, A. G.; Bart, V. A.; Steland, A.; Zaslavskiy, M. L.
In: Journal of Statistical Planning and Inference, Vol. 132, No. 1-2 SPEC. ISS., 01.06.2005, p. 33-51.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Modeling disease dynamics and survivor functions by sanogenesis curves
AU - Bart, A. G.
AU - Bart, V. A.
AU - Steland, A.
AU - Zaslavskiy, M. L.
PY - 2005/6/1
Y1 - 2005/6/1
N2 - We propose to analyse the development of a disease by sanogenesis curves which model the result of interacting exitatory and inhibitory factors on a disease. Assuming that high-dimensional data describing the disease course are driven by a latent complex-valued Gaussian process with Markovian structure, we can identify the sanogenesis curve as the real part of the covariance function of the latent process. By applying techniques of stochastic process theory and partially inverse functions theory this finding allows to estimate the model parameters. In addition, the sanogensis curve also suggests a new model for survival times, where failures (deads) are only observed during critical time periods (crises) defined by the sanogenesis curve. We illustrate our approach by analyzing two real data sets from medicine.
AB - We propose to analyse the development of a disease by sanogenesis curves which model the result of interacting exitatory and inhibitory factors on a disease. Assuming that high-dimensional data describing the disease course are driven by a latent complex-valued Gaussian process with Markovian structure, we can identify the sanogenesis curve as the real part of the covariance function of the latent process. By applying techniques of stochastic process theory and partially inverse functions theory this finding allows to estimate the model parameters. In addition, the sanogensis curve also suggests a new model for survival times, where failures (deads) are only observed during critical time periods (crises) defined by the sanogenesis curve. We illustrate our approach by analyzing two real data sets from medicine.
KW - Confidence regions
KW - Correlation function
KW - Critical and latent time points
KW - Factor analysis
KW - Partially inverse function
KW - Sanogenesis curve
KW - Survivor function
UR - http://www.scopus.com/inward/record.url?scp=15844366564&partnerID=8YFLogxK
U2 - 10.1016/j.jspi.2004.06.014
DO - 10.1016/j.jspi.2004.06.014
M3 - Article
AN - SCOPUS:15844366564
VL - 132
SP - 33
EP - 51
JO - Journal of Statistical Planning and Inference
JF - Journal of Statistical Planning and Inference
SN - 0378-3758
IS - 1-2 SPEC. ISS.
ER -
ID: 61819181