Mixed-ligand copper(II) complexes with tetrazole derivatives and 2,2′-bipyridine, 1,10-phenanthroline : Synthesis, structure and cytotoxic activity. / Eremina, Julia A.; Lider, Elizaveta V.; Samsonenko, Denis G.; Sheludyakova, Liliya A.; Berezin, Alexey S.; Klyushova, Lyubov S.; Ostrovskii, Vladimir A.; Trifonov, Rostislav E.
In: Inorganica Chimica Acta, Vol. 487, 01.03.2019, p. 138-144.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Mixed-ligand copper(II) complexes with tetrazole derivatives and 2,2′-bipyridine, 1,10-phenanthroline
T2 - Synthesis, structure and cytotoxic activity
AU - Eremina, Julia A.
AU - Lider, Elizaveta V.
AU - Samsonenko, Denis G.
AU - Sheludyakova, Liliya A.
AU - Berezin, Alexey S.
AU - Klyushova, Lyubov S.
AU - Ostrovskii, Vladimir A.
AU - Trifonov, Rostislav E.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - The [Cu2(2,2′-bipy)2(L1)4] (1), [Cu2(1,10-phen)2(L1)4] (2), [Cu(2,2′-bipy)(L2)2]n (3) and [Cu2(1,10-phen)2(L2)4] (4) complexes, where HL1 – 5-phenyltetrazole, and HL2 – 1H-tetrazole, have been synthesized. All complexes have been characterized by elemental analysis, IR, EPR spectroscopy and X-ray diffraction. The complexes possess distorted tetragonal-pyramidal coordination geometry. Compounds 1, 2, 4 show μ-5-phenyl-tetrazole/tetrazole bridged dinuclear structures, while compound 3 reveals polymeric structure. The effect of compounds on viability of the MCF-7 and Hep-2 cell lines was investigated in vitro. The study showed that tetrazole ligands HL1 and HL2 are non-toxic at tested concentrations (1–50 μM), while 1,10-phen and 2,2′-bipy posses cytotoxicity. All of the complexes exhibit significant dose-dependent cytotoxic effect and have the potential to act as efficient cytotoxic drugs. The complexes [Cu(1,10-phen)Cl2] (5) and [Cu(2,2′-bipy)Cl2] (6) have also been obtained to establish the influence of insertion of tetrazole ligands in compounds on their cytotoxic properties.
AB - The [Cu2(2,2′-bipy)2(L1)4] (1), [Cu2(1,10-phen)2(L1)4] (2), [Cu(2,2′-bipy)(L2)2]n (3) and [Cu2(1,10-phen)2(L2)4] (4) complexes, where HL1 – 5-phenyltetrazole, and HL2 – 1H-tetrazole, have been synthesized. All complexes have been characterized by elemental analysis, IR, EPR spectroscopy and X-ray diffraction. The complexes possess distorted tetragonal-pyramidal coordination geometry. Compounds 1, 2, 4 show μ-5-phenyl-tetrazole/tetrazole bridged dinuclear structures, while compound 3 reveals polymeric structure. The effect of compounds on viability of the MCF-7 and Hep-2 cell lines was investigated in vitro. The study showed that tetrazole ligands HL1 and HL2 are non-toxic at tested concentrations (1–50 μM), while 1,10-phen and 2,2′-bipy posses cytotoxicity. All of the complexes exhibit significant dose-dependent cytotoxic effect and have the potential to act as efficient cytotoxic drugs. The complexes [Cu(1,10-phen)Cl2] (5) and [Cu(2,2′-bipy)Cl2] (6) have also been obtained to establish the influence of insertion of tetrazole ligands in compounds on their cytotoxic properties.
KW - 1,10-Phenanthroline
KW - Cytotoxicity
KW - Hep-2
KW - MCF-7
KW - Mixed ligand Cu(II) complexes
KW - Tetrazole
UR - http://www.scopus.com/inward/record.url?scp=85058157945&partnerID=8YFLogxK
U2 - 10.1016/j.ica.2018.12.011
DO - 10.1016/j.ica.2018.12.011
M3 - Article
AN - SCOPUS:85058157945
VL - 487
SP - 138
EP - 144
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
SN - 0020-1693
ER -
ID: 51239243