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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence. / Anisimov, V. N.; Bakeeva, L. E.; Egormin, P. A.; Filenko, O. F.; Isakova, E. F.; Manskikh, V. N.; Mikhelson, V. M.; Panteleeva, A. A.; Pasyukova, E. G.; Pilipenko, D. I.; Piskunova, T. S.; Popovich, I. G.; Roshchina, N. V.; Rybina, O. Yu; Saprunova, V. B.; Samoylova, T. A.; Semenchenko, A. V.; Skulachev, M. V.; Spivak, I. M.; Tsybul'Ko, E. A.; Tyndyk, M. L.; Vyssokikh, M. Yu; Yurova, M. N.; Zabezhinsky, M. A.; Skulachev, V. P.
In:
Biochemistry (Moscow), Vol. 73, No. 12, 01.12.2008, p. 1329-1342.
Research output: Contribution to journal › Article › peer-review
Harvard
Anisimov, VN, Bakeeva, LE, Egormin, PA, Filenko, OF, Isakova, EF, Manskikh, VN, Mikhelson, VM, Panteleeva, AA, Pasyukova, EG, Pilipenko, DI, Piskunova, TS, Popovich, IG, Roshchina, NV, Rybina, OY, Saprunova, VB, Samoylova, TA, Semenchenko, AV, Skulachev, MV
, Spivak, IM, Tsybul'Ko, EA, Tyndyk, ML, Vyssokikh, MY, Yurova, MN, Zabezhinsky, MA & Skulachev, VP 2008, '
Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence',
Biochemistry (Moscow), vol. 73, no. 12, pp. 1329-1342.
https://doi.org/10.1134/S0006297908120055APA
Anisimov, V. N., Bakeeva, L. E., Egormin, P. A., Filenko, O. F., Isakova, E. F., Manskikh, V. N., Mikhelson, V. M., Panteleeva, A. A., Pasyukova, E. G., Pilipenko, D. I., Piskunova, T. S., Popovich, I. G., Roshchina, N. V., Rybina, O. Y., Saprunova, V. B., Samoylova, T. A., Semenchenko, A. V., Skulachev, M. V.
, Spivak, I. M., ... Skulachev, V. P. (2008).
Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence.
Biochemistry (Moscow),
73(12), 1329-1342.
https://doi.org/10.1134/S0006297908120055Vancouver
Author
Anisimov, V. N. ; Bakeeva, L. E. ; Egormin, P. A. ; Filenko, O. F. ; Isakova, E. F. ; Manskikh, V. N. ; Mikhelson, V. M. ; Panteleeva, A. A. ; Pasyukova, E. G. ; Pilipenko, D. I. ; Piskunova, T. S. ; Popovich, I. G. ; Roshchina, N. V. ; Rybina, O. Yu ; Saprunova, V. B. ; Samoylova, T. A. ; Semenchenko, A. V. ; Skulachev, M. V.
; Spivak, I. M. ; Tsybul'Ko, E. A. ; Tyndyk, M. L. ; Vyssokikh, M. Yu ; Yurova, M. N. ; Zabezhinsky, M. A. ; Skulachev, V. P. /
Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence. In:
Biochemistry (Moscow). 2008 ; Vol. 73, No. 12. pp. 1329-1342.
BibTeX
@article{2a732f2aa38d438e9117cd18c0117700,
title = "Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence",
abstract = "Very low (nano- and subnanomolar) concentrations of 10-(6′- plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong lifespan of a fungus (Podospora anserina), a crustacean (Ceriodaphnia affinis), an insect (Drosophila melanogaster), and a mammal (mouse). In the latter case, median lifespan is doubled if animals live in a non-sterile vivarium. The lifespan increase is accompanied by rectangularization of the survival curves (an increase in survival is much larger at early than at late ages) and disappearance of typical traits of senescence or retardation of their development. Data summarized here and in the preceding papers of this series suggest that mitochondria-targeted antioxidant SkQ1 is competent in slowing down execution of an aging program responsible for development of age-related senescence.",
keywords = "Aging, Antioxidants, Mitochondria, Senescence, SkQ1, Therapy",
author = "Anisimov, {V. N.} and Bakeeva, {L. E.} and Egormin, {P. A.} and Filenko, {O. F.} and Isakova, {E. F.} and Manskikh, {V. N.} and Mikhelson, {V. M.} and Panteleeva, {A. A.} and Pasyukova, {E. G.} and Pilipenko, {D. I.} and Piskunova, {T. S.} and Popovich, {I. G.} and Roshchina, {N. V.} and Rybina, {O. Yu} and Saprunova, {V. B.} and Samoylova, {T. A.} and Semenchenko, {A. V.} and Skulachev, {M. V.} and Spivak, {I. M.} and Tsybul'Ko, {E. A.} and Tyndyk, {M. L.} and Vyssokikh, {M. Yu} and Yurova, {M. N.} and Zabezhinsky, {M. A.} and Skulachev, {V. P.}",
year = "2008",
month = dec,
day = "1",
doi = "10.1134/S0006297908120055",
language = "English",
volume = "73",
pages = "1329--1342",
journal = "Biochemistry (Moscow)",
issn = "0006-2979",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "12",
}
RIS
TY - JOUR
T1 - Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence
AU - Anisimov, V. N.
AU - Bakeeva, L. E.
AU - Egormin, P. A.
AU - Filenko, O. F.
AU - Isakova, E. F.
AU - Manskikh, V. N.
AU - Mikhelson, V. M.
AU - Panteleeva, A. A.
AU - Pasyukova, E. G.
AU - Pilipenko, D. I.
AU - Piskunova, T. S.
AU - Popovich, I. G.
AU - Roshchina, N. V.
AU - Rybina, O. Yu
AU - Saprunova, V. B.
AU - Samoylova, T. A.
AU - Semenchenko, A. V.
AU - Skulachev, M. V.
AU - Spivak, I. M.
AU - Tsybul'Ko, E. A.
AU - Tyndyk, M. L.
AU - Vyssokikh, M. Yu
AU - Yurova, M. N.
AU - Zabezhinsky, M. A.
AU - Skulachev, V. P.
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Very low (nano- and subnanomolar) concentrations of 10-(6′- plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong lifespan of a fungus (Podospora anserina), a crustacean (Ceriodaphnia affinis), an insect (Drosophila melanogaster), and a mammal (mouse). In the latter case, median lifespan is doubled if animals live in a non-sterile vivarium. The lifespan increase is accompanied by rectangularization of the survival curves (an increase in survival is much larger at early than at late ages) and disappearance of typical traits of senescence or retardation of their development. Data summarized here and in the preceding papers of this series suggest that mitochondria-targeted antioxidant SkQ1 is competent in slowing down execution of an aging program responsible for development of age-related senescence.
AB - Very low (nano- and subnanomolar) concentrations of 10-(6′- plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong lifespan of a fungus (Podospora anserina), a crustacean (Ceriodaphnia affinis), an insect (Drosophila melanogaster), and a mammal (mouse). In the latter case, median lifespan is doubled if animals live in a non-sterile vivarium. The lifespan increase is accompanied by rectangularization of the survival curves (an increase in survival is much larger at early than at late ages) and disappearance of typical traits of senescence or retardation of their development. Data summarized here and in the preceding papers of this series suggest that mitochondria-targeted antioxidant SkQ1 is competent in slowing down execution of an aging program responsible for development of age-related senescence.
KW - Aging
KW - Antioxidants
KW - Mitochondria
KW - Senescence
KW - SkQ1
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=58149485086&partnerID=8YFLogxK
U2 - 10.1134/S0006297908120055
DO - 10.1134/S0006297908120055
M3 - Article
C2 - 19120018
VL - 73
SP - 1329
EP - 1342
JO - Biochemistry (Moscow)
JF - Biochemistry (Moscow)
SN - 0006-2979
IS - 12
ER -
