Research output: Contribution to journal › Review article › peer-review
Mitochondrial proteins as biomarkers of cellular senescence and age-associated diseases. / Panfilova, A.; Zubareva, T.; Mironova, E.; Mazzoccoli, G.; Marasco, M.G.P.; Balazovskaia, S.; Yablonsky, P.; Kvetnoǐ, I.
In: Aging, Vol. 17, No. 9, 25.08.2025, p. 2430-2448.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Mitochondrial proteins as biomarkers of cellular senescence and age-associated diseases
AU - Panfilova, A.
AU - Zubareva, T.
AU - Mironova, E.
AU - Mazzoccoli, G.
AU - Marasco, M.G.P.
AU - Balazovskaia, S.
AU - Yablonsky, P.
AU - Kvetnoǐ, I.
N1 - Export Date: 01 November 2025; Cited By: 0; Correspondence Address: E. Mironova; Saint-Petersburg Research Institute of Phthisiopulmonology, Saint-Petersburg, 191036, Russian Federation; email: katrine1994@mail.ru
PY - 2025/8/25
Y1 - 2025/8/25
N2 - Research in the field of mitochondrial biomarkers plays an important role in understanding the processes of cellular aging. Mitochondria are not only the energy centers of the cell, but also key regulators of signaling within the cell. They significantly affect the life and function of the cell. The aging process of cells is associated with various factors, including DNA damage, disruption of the cell cycle, changes in mitochondria, and problems with signal transmission. Mitochondrial dysfunction is a major contributor to cellular and organismal aging. As we age, there is an accumulation of dysfunctional mitochondria, leading to decreased efficiency of oxidative phosphorylation and increased production of reactive oxygen species. This review focuses on the main mitochondrial markers involved in the mechanisms of cell aging: DRP1, Prohibitin, Parkin, PINK1, MFF, VDAC, TOM. These signaling molecules are involved in mitochondrial fission and the mechanisms of mitochondria-dependent apoptosis, in the regulation of mitochondrial respiratory activity, ensuring the stability of the organization and copying of mitochondrial DNA, protecting cells from oxidative stress, in the process of autophagy of damaged mitochondria, in protective mechanisms during stress-induced mitochondrial dysfunction. Analysis of mitochondrial markers can provide valuable information about the state of cells and their functional significance at various stages of aging, which could promote our understanding of cellular aging mechanisms and developing corrective methods. These insights highlight mitochondrial proteins as potential therapeutic targets to combat age-related diseases. © 2025 Elsevier B.V., All rights reserved.
AB - Research in the field of mitochondrial biomarkers plays an important role in understanding the processes of cellular aging. Mitochondria are not only the energy centers of the cell, but also key regulators of signaling within the cell. They significantly affect the life and function of the cell. The aging process of cells is associated with various factors, including DNA damage, disruption of the cell cycle, changes in mitochondria, and problems with signal transmission. Mitochondrial dysfunction is a major contributor to cellular and organismal aging. As we age, there is an accumulation of dysfunctional mitochondria, leading to decreased efficiency of oxidative phosphorylation and increased production of reactive oxygen species. This review focuses on the main mitochondrial markers involved in the mechanisms of cell aging: DRP1, Prohibitin, Parkin, PINK1, MFF, VDAC, TOM. These signaling molecules are involved in mitochondrial fission and the mechanisms of mitochondria-dependent apoptosis, in the regulation of mitochondrial respiratory activity, ensuring the stability of the organization and copying of mitochondrial DNA, protecting cells from oxidative stress, in the process of autophagy of damaged mitochondria, in protective mechanisms during stress-induced mitochondrial dysfunction. Analysis of mitochondrial markers can provide valuable information about the state of cells and their functional significance at various stages of aging, which could promote our understanding of cellular aging mechanisms and developing corrective methods. These insights highlight mitochondrial proteins as potential therapeutic targets to combat age-related diseases. © 2025 Elsevier B.V., All rights reserved.
KW - age-associated diseases
KW - biomarkers
KW - cellular senescence
KW - mitochondria
KW - mitochondrial proteins
KW - biological marker
KW - mitochondrial DNA
KW - mitochondrial protein
KW - parkin
KW - prohibitin
KW - reactive oxygen metabolite
KW - aging
KW - apoptosis
KW - autophagy (cellular)
KW - cell aging
KW - cell cycle
KW - DNA damage
KW - drug therapy
KW - mitochondrial dynamics
KW - mitochondrion
KW - nonhuman
KW - oxidative phosphorylation
KW - oxidative stress
KW - pharmacology
KW - review
KW - signal transduction
KW - animal
KW - human
KW - metabolism
KW - physiology
KW - Aging
KW - Animals
KW - Biomarkers
KW - Cellular Senescence
KW - Humans
KW - Mitochondria
KW - Mitochondrial Proteins
KW - Mitochondria/metabolism
KW - Aging/metabolism
KW - Biomarkers/metabolism
KW - Mitochondrial Proteins/metabolism
KW - Cellular Senescence/physiology
UR - https://www.mendeley.com/catalogue/236d8c00-7322-36e4-92af-b4dbfc30f401/
U2 - 10.18632/aging.206305
DO - 10.18632/aging.206305
M3 - Обзорная статья
C2 - 40856658
VL - 17
SP - 2430
EP - 2448
JO - Aging
JF - Aging
SN - 1945-4589
IS - 9
ER -
ID: 143730552