Results of synchronous microwave monitoring of middle atmosphere ozone in Apatity (67° N, 33° E) and Peterhof (60° N, 30° E) during the winter and spring of 2021/2022 are presented. Identical mobile microwave spectrometers with an observation frequency of 110.8 GHz were used for ozone measurements. These instruments have identical techniques for observations and estimation of ozone profiles at the altitudes of 22–60 km. The main attention was given to changes in ozone (daily variations) in the mesosphere during the polar night and dynamic disturbances. To interpret the mesospheric ozone (60 km) behavior, MLS/Aura satellite data on the vertical distribution of temperature in the middle atmosphere over Apatity were used.