High-resolution electron backscatter diffraction (EBSD) was applied to examine grain refinement in commercial-purity titanium Grade 4 subjected to equal-channel angular pressing (ECAP) via the Conform technique. This approach enables the production of long-length billets and thus has the potential for commercial application. Microstructure evolution was found to be a relatively-complex process which included several stages. At relatively-low accumulated strains, microstructure changes were markedly influenced by mechanical twinning. However, the concomitant grain refinement suppressed this mechanism, and subsequent microstructure development was dictated by the evolution of deformation-induced boundaries which developed preferentially near the original grain boundaries. The final material produced after an effective strain of ~ 8.4 was characterized by a mean grain size of 0.3 µm, high-angle boundary fraction of 55 pct., a texture of moderate strength, and a yield strength of ~ 1050 MPa. Based on the detailed microstructural analysis, the contributions of various strengthening mechanisms were quantified. The rapid material strengthening during the early stages of ECAP was explained in the terms of a major increase in dislocation density and the extensive formation of the deformation-induced boundaries. With further increments in accumulated strain, however, the dislocation as well as grain-boundary density reached a saturation, thus reducing the hardening efficiency of ECAP at high strains.