Microextraction of Tetracyclines from Milk to Deep Eutectic Solvents for the Subsequent Determination by High-Performance Liquid Chromatography–Tandem Mass Spectrometry

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Microextraction of Tetracyclines from Milk to Deep Eutectic Solvents for the Subsequent Determination by High-Performance Liquid Chromatography–Tandem Mass Spectrometry. / Cherkashina, K. D. ; Pochivalov, A. S. ; Shakirova, F. M. ; Shishov, A. Yu. ; Bulatov, A. V. .

In: Journal of Analytical Chemistry, Vol. 77, No. 3, 01.03.2022, p. 334-341.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{0e9694a8a65e4d0aa2e5ded9a526a566,

title = "Microextraction of Tetracyclines from Milk to Deep Eutectic Solvents for the Subsequent Determination by High-Performance Liquid Chromatography–Tandem Mass Spectrometry",

abstract = "A method of liquid–liquid microextraction is proposed for the extraction and preconcentration of tetracycline antibiotics from milk. It involves the extraction of analytes into a hydrophobic deep eutectic solvent (DES) based on a terpenoid and a carboxylic acid, followed by back extraction into the aqueous phase. A synergistic effect was revealed in the microextraction of tetracyclines into a DES phase based on thymol and octanoic acid (molar ratio of precursors 0.35 : 0.65), i.e., higher distribution ratios compared to those calculated using the additive scheme. Possibilities of the proposed method are shown on an example of the determination of tetracycline, chlortetracycline, and doxycycline in milk samples by HPLC–MS/MS. The limits of detection (3σ) for tetracycline and doxycycline are 5 ng/kg and for chlortetracycline,—50 ng/kg.",

keywords = "liquid–liquid microextraction, deep eutectic solvents, tetracyclines, food products, High-performance liquid chromatography, high-performance liquid chromatography",

author = "Cherkashina, {K. D.} and Pochivalov, {A. S.} and Shakirova, {F. M.} and Shishov, {A. Yu.} and Bulatov, {A. V.}",

note = "Publisher Copyright: {\textcopyright} 2022, Pleiades Publishing, Ltd.",

year = "2022",

month = mar,

day = "1",

doi = "10.1134/s1061934822030042",

language = "English",

volume = "77",

pages = "334--341",

journal = "Journal of Analytical Chemistry",

issn = "1061-9348",

publisher = "МАИК {"}Наука/Интерпериодика{"}",

number = "3",

}

RIS

TY - JOUR

T1 - Microextraction of Tetracyclines from Milk to Deep Eutectic Solvents for the Subsequent Determination by High-Performance Liquid Chromatography–Tandem Mass Spectrometry

AU - Cherkashina, K. D.

AU - Pochivalov, A. S.

AU - Shakirova, F. M.

AU - Shishov, A. Yu.

AU - Bulatov, A. V.

PY - 2022/3/1

Y1 - 2022/3/1

N2 - A method of liquid–liquid microextraction is proposed for the extraction and preconcentration of tetracycline antibiotics from milk. It involves the extraction of analytes into a hydrophobic deep eutectic solvent (DES) based on a terpenoid and a carboxylic acid, followed by back extraction into the aqueous phase. A synergistic effect was revealed in the microextraction of tetracyclines into a DES phase based on thymol and octanoic acid (molar ratio of precursors 0.35 : 0.65), i.e., higher distribution ratios compared to those calculated using the additive scheme. Possibilities of the proposed method are shown on an example of the determination of tetracycline, chlortetracycline, and doxycycline in milk samples by HPLC–MS/MS. The limits of detection (3σ) for tetracycline and doxycycline are 5 ng/kg and for chlortetracycline,—50 ng/kg.

AB - A method of liquid–liquid microextraction is proposed for the extraction and preconcentration of tetracycline antibiotics from milk. It involves the extraction of analytes into a hydrophobic deep eutectic solvent (DES) based on a terpenoid and a carboxylic acid, followed by back extraction into the aqueous phase. A synergistic effect was revealed in the microextraction of tetracyclines into a DES phase based on thymol and octanoic acid (molar ratio of precursors 0.35 : 0.65), i.e., higher distribution ratios compared to those calculated using the additive scheme. Possibilities of the proposed method are shown on an example of the determination of tetracycline, chlortetracycline, and doxycycline in milk samples by HPLC–MS/MS. The limits of detection (3σ) for tetracycline and doxycycline are 5 ng/kg and for chlortetracycline,—50 ng/kg.

KW - liquid–liquid microextraction

KW - deep eutectic solvents

KW - tetracyclines

KW - food products

KW - High-performance liquid chromatography

KW - high-performance liquid chromatography

UR - https://link.springer.com/article/10.1134/S1061934822030042

UR - http://www.scopus.com/inward/record.url?scp=85127511829&partnerID=8YFLogxK

U2 - 10.1134/s1061934822030042

DO - 10.1134/s1061934822030042

M3 - Article

VL - 77

SP - 334

EP - 341

JO - Journal of Analytical Chemistry

JF - Journal of Analytical Chemistry

SN - 1061-9348

IS - 3

ER -

ID: 94819197