The main objects of our investigation are cyber-physical-socio space and systems (CPSS). The cyber-physical-socio space is the fusion of the physical space, the cyber space, and the socio space. The problem of CPSS complexity management and control is modern and current. The solution of this problem involves interdisciplinary research studies by specialists in mathematics, economics, sociology, biology, physics, and computer technologies. However, the founders of cybernetics imparted to its laws much more universality than is really considered in today's social and business systems. Therefore, the paper presents the results of the methodological and technical basis for interdisciplinary investigation and development in the field of CPSS, which are interrelated with a new scientific branch named neocybernetics.