Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats

Standard

Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats. / Bekusova, Viktoria V.; Patsanovskii, Vasily M.; Nozdrachev, Alexander D.; Trashkov, Alexandr P.; Artemenko, Margarita R.; Anisimov, Vladimir N.

In: Cancer Biology and Medicine, Vol. 14, No. 1, 01.03.2017, p. 100-107.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{979e7ca0de6b400893206201cf9ee4e3,

title = "Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats",

abstract = "Effects of two doses of the anti-diabetic drug, metformin (MF), on hormonal and metabolic levels of serum of non-diabetic male Wistar rats with 1,2-dimethylhydrazine (DMH)-induced colon tumor adenocarcinomas were studied. Carcinogenesis in the animals was also observed. Rats with DMH-induced colon adenocarcinomas had elevated levels of serum glucose, insulin, insulinlike growth factor-1, total cholesterol, triglycerides, catalase, malonic dialdehyde, glycated hemoglobin, aspartate aminotransferase, and alanine aminotransferase and decreased hemoglobin. Treatment with two doses of MF normalized majority of these changes in DMH-treated rats, whereas the drug was ineffective in rats without DMH treatment. The only exception was the decreased triglyceride levels in MF-treated rats. A 100 mg/kg dose of MF increased DMH-induced exophytic colon carcinomas and decreased endophytic tumors compared with untreated rats. Moreover, both MF doses increased DMH-induced and highly differentiated tumors and decreased the invasiveness of colon carcinomas compared with rats provided with DMH and water. Therefore, effects of MF on metabolic homeostasis are critical for preventing colon cancer.",

keywords = "1,2-dimethylhydrazine, Colon cancer, Metformin, Prevention, Rat",

author = "Bekusova, {Viktoria V.} and Patsanovskii, {Vasily M.} and Nozdrachev, {Alexander D.} and Trashkov, {Alexandr P.} and Artemenko, {Margarita R.} and Anisimov, {Vladimir N.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2017 by Cancer Biology & Medicine.",

year = "2017",

month = mar,

day = "1",

doi = "10.20892/j.issn.2095-3941.2016.0088",

language = "English",

volume = "14",

pages = "100--107",

journal = "Cancer Biology and Medicine",

issn = "2095-3941",

publisher = "Chinese Anticancer Association",

number = "1",

}

RIS

TY - JOUR

T1 - Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats

AU - Bekusova, Viktoria V.

AU - Patsanovskii, Vasily M.

AU - Nozdrachev, Alexander D.

AU - Trashkov, Alexandr P.

AU - Artemenko, Margarita R.

AU - Anisimov, Vladimir N.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Effects of two doses of the anti-diabetic drug, metformin (MF), on hormonal and metabolic levels of serum of non-diabetic male Wistar rats with 1,2-dimethylhydrazine (DMH)-induced colon tumor adenocarcinomas were studied. Carcinogenesis in the animals was also observed. Rats with DMH-induced colon adenocarcinomas had elevated levels of serum glucose, insulin, insulinlike growth factor-1, total cholesterol, triglycerides, catalase, malonic dialdehyde, glycated hemoglobin, aspartate aminotransferase, and alanine aminotransferase and decreased hemoglobin. Treatment with two doses of MF normalized majority of these changes in DMH-treated rats, whereas the drug was ineffective in rats without DMH treatment. The only exception was the decreased triglyceride levels in MF-treated rats. A 100 mg/kg dose of MF increased DMH-induced exophytic colon carcinomas and decreased endophytic tumors compared with untreated rats. Moreover, both MF doses increased DMH-induced and highly differentiated tumors and decreased the invasiveness of colon carcinomas compared with rats provided with DMH and water. Therefore, effects of MF on metabolic homeostasis are critical for preventing colon cancer.

AB - Effects of two doses of the anti-diabetic drug, metformin (MF), on hormonal and metabolic levels of serum of non-diabetic male Wistar rats with 1,2-dimethylhydrazine (DMH)-induced colon tumor adenocarcinomas were studied. Carcinogenesis in the animals was also observed. Rats with DMH-induced colon adenocarcinomas had elevated levels of serum glucose, insulin, insulinlike growth factor-1, total cholesterol, triglycerides, catalase, malonic dialdehyde, glycated hemoglobin, aspartate aminotransferase, and alanine aminotransferase and decreased hemoglobin. Treatment with two doses of MF normalized majority of these changes in DMH-treated rats, whereas the drug was ineffective in rats without DMH treatment. The only exception was the decreased triglyceride levels in MF-treated rats. A 100 mg/kg dose of MF increased DMH-induced exophytic colon carcinomas and decreased endophytic tumors compared with untreated rats. Moreover, both MF doses increased DMH-induced and highly differentiated tumors and decreased the invasiveness of colon carcinomas compared with rats provided with DMH and water. Therefore, effects of MF on metabolic homeostasis are critical for preventing colon cancer.

KW - 1,2-dimethylhydrazine

KW - Colon cancer

KW - Metformin

KW - Prevention

KW - Rat

UR - http://www.scopus.com/inward/record.url?scp=85017131496&partnerID=8YFLogxK

U2 - 10.20892/j.issn.2095-3941.2016.0088

DO - 10.20892/j.issn.2095-3941.2016.0088

M3 - Article

AN - SCOPUS:85017131496

VL - 14

SP - 100

EP - 107

JO - Cancer Biology and Medicine

JF - Cancer Biology and Medicine

SN - 2095-3941

IS - 1

ER -

ID: 99497713