Research output: Contribution to journal › Review article › peer-review
Metabolomic biomarkers in gynecology : A treasure path or a false path? / Govorov, Igor; Sitkin, Stanislav; Pervunina, Tatyana; Moskvin, Alexey; Baranenko, Denis; Komlichenko, Eduard.
In: Current Medicinal Chemistry, Vol. 27, No. 22, 2020, p. 3611-3622.Research output: Contribution to journal › Review article › peer-review
}
TY - JOUR
T1 - Metabolomic biomarkers in gynecology
T2 - A treasure path or a false path?
AU - Govorov, Igor
AU - Sitkin, Stanislav
AU - Pervunina, Tatyana
AU - Moskvin, Alexey
AU - Baranenko, Denis
AU - Komlichenko, Eduard
N1 - Publisher Copyright: © 2020 Bentham Science Publishers.
PY - 2020
Y1 - 2020
N2 - Omic-technologies (genomics, transcriptomics, proteomics and metabolomics) have become more important in current medical science. Among them, it is metabolomics that most accurately reflects the minor changes in body functioning, as it focuses on metabolome – the group of the metabolism products, both intermediate and end. Therefore, metabolomics is actively engaged in fundamental and clinical studies and search for potential biomarkers. The biomarker could be used in diagnostics, management and stratification of the patients, as well as in prognosing the outcomes. The good example is gynecology, since many gynecological diseases lack effective biomarkers. In the current review, we aimed to summarize the results of the studies, devoted to the search of potential metabolomic biomarkers for the most common gynecological diseases.
AB - Omic-technologies (genomics, transcriptomics, proteomics and metabolomics) have become more important in current medical science. Among them, it is metabolomics that most accurately reflects the minor changes in body functioning, as it focuses on metabolome – the group of the metabolism products, both intermediate and end. Therefore, metabolomics is actively engaged in fundamental and clinical studies and search for potential biomarkers. The biomarker could be used in diagnostics, management and stratification of the patients, as well as in prognosing the outcomes. The good example is gynecology, since many gynecological diseases lack effective biomarkers. In the current review, we aimed to summarize the results of the studies, devoted to the search of potential metabolomic biomarkers for the most common gynecological diseases.
KW - Biomarkers
KW - Endometriosis
KW - Gynecology
KW - Leiomyoma
KW - Metabolomics
KW - Ovarian neoplasms
KW - Polycystic ovary syndrome
KW - Uterine cervical neoplasms
UR - http://www.scopus.com/inward/record.url?scp=85087445676&partnerID=8YFLogxK
U2 - 10.2174/0929867326666190104124245
DO - 10.2174/0929867326666190104124245
M3 - Review article
C2 - 30608036
AN - SCOPUS:85087445676
VL - 27
SP - 3611
EP - 3622
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
SN - 0929-8673
IS - 22
ER -
ID: 87784368