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Melatonin treatment reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish. / Giacomini, Ana C.V.V.; Teixeira, Kauane H.; Marcon, Leticia; Scolari, Naiara; Bueno, Barbara W.; Genario, Rafael; de Abreu, Natascha S.; Demin, Konstantin A.; Galstyan, David S.; Kalueff, Allan V.; de Abreu, Murilo S.

In: Neuroscience Letters, Vol. 733, 135073, 10.08.2020.

Research output: Contribution to journal › Article › peer-review

Harvard

Giacomini, ACVV, Teixeira, KH, Marcon, L, Scolari, N, Bueno, BW, Genario, R, de Abreu, NS, Demin, KA, Galstyan, DS, Kalueff, AV & de Abreu, MS 2020, 'Melatonin treatment reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish', Neuroscience Letters, vol. 733, 135073. https://doi.org/10.1016/j.neulet.2020.135073

APA

Giacomini, A. C. V. V., Teixeira, K. H., Marcon, L., Scolari, N., Bueno, B. W., Genario, R., de Abreu, N. S., Demin, K. A., Galstyan, D. S., Kalueff, A. V., & de Abreu, M. S. (2020). Melatonin treatment reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish. Neuroscience Letters, 733, [135073]. https://doi.org/10.1016/j.neulet.2020.135073

Vancouver

Giacomini ACVV, Teixeira KH, Marcon L, Scolari N, Bueno BW, Genario R et al. Melatonin treatment reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish. Neuroscience Letters. 2020 Aug 10;733. 135073. https://doi.org/10.1016/j.neulet.2020.135073

Author

Giacomini, Ana C.V.V. ; Teixeira, Kauane H. ; Marcon, Leticia ; Scolari, Naiara ; Bueno, Barbara W. ; Genario, Rafael ; de Abreu, Natascha S. ; Demin, Konstantin A. ; Galstyan, David S. ; Kalueff, Allan V. ; de Abreu, Murilo S. / Melatonin treatment reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish. In: Neuroscience Letters. 2020 ; Vol. 733.

BibTeX

@article{feec0cce59c44da9bcadfc6b763ee765,
title = "Melatonin treatment reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish",
abstract = "Melatonin is an important pineal hormone that regulates human and animal circadian rhythms and sleep. Mounting clinical and rodent evidence indicates that melatonin also modulates affective behaviors and cognition. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model organism in translational neuroscience research. Here, we evaluate the effects of a 24-h melatonin treatment on behavior and physiology of adult zebrafish with circadian rhythm disturbed by a 24-h light exposure. While such light exposure evoked overt cognitive and neuroendocrine (cortisol) deficits in zebrafish, these effects were reversed by a 24-h melatonin treatment. Collectively, these findings suggest a positive modulation of affective and cognitive phenotypes in zebrafish by melatonin, and reinforce the growing utility of zebrafish models for studying circadian, cognitive and behavioral processes and their neuroendocrine regulation in vivo.",
keywords = "Cognition, Cortisol, Light cycle, Melatonin, Zebrafish, EFFICACY, DYSFUNCTIONS, CIRCADIAN-RHYTHMS, SLEEP-DEPRIVATION, CHRONIC MILD STRESS, SCOPOLAMINE, MODEL, ANXIETY-LIKE BEHAVIOR, INDUCED MEMORY IMPAIRMENT, LIVER-ENZYMES",
author = "Giacomini, {Ana C.V.V.} and Teixeira, {Kauane H.} and Leticia Marcon and Naiara Scolari and Bueno, {Barbara W.} and Rafael Genario and {de Abreu}, {Natascha S.} and Demin, {Konstantin A.} and Galstyan, {David S.} and Kalueff, {Allan V.} and {de Abreu}, {Murilo S.}",
year = "2020",
month = aug,
day = "10",
doi = "10.1016/j.neulet.2020.135073",
language = "English",
volume = "733",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Melatonin treatment reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish

AU - Giacomini, Ana C.V.V.

AU - Teixeira, Kauane H.

AU - Marcon, Leticia

AU - Scolari, Naiara

AU - Bueno, Barbara W.

AU - Genario, Rafael

AU - de Abreu, Natascha S.

AU - Demin, Konstantin A.

AU - Galstyan, David S.

AU - Kalueff, Allan V.

AU - de Abreu, Murilo S.

PY - 2020/8/10

Y1 - 2020/8/10

N2 - Melatonin is an important pineal hormone that regulates human and animal circadian rhythms and sleep. Mounting clinical and rodent evidence indicates that melatonin also modulates affective behaviors and cognition. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model organism in translational neuroscience research. Here, we evaluate the effects of a 24-h melatonin treatment on behavior and physiology of adult zebrafish with circadian rhythm disturbed by a 24-h light exposure. While such light exposure evoked overt cognitive and neuroendocrine (cortisol) deficits in zebrafish, these effects were reversed by a 24-h melatonin treatment. Collectively, these findings suggest a positive modulation of affective and cognitive phenotypes in zebrafish by melatonin, and reinforce the growing utility of zebrafish models for studying circadian, cognitive and behavioral processes and their neuroendocrine regulation in vivo.

AB - Melatonin is an important pineal hormone that regulates human and animal circadian rhythms and sleep. Mounting clinical and rodent evidence indicates that melatonin also modulates affective behaviors and cognition. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model organism in translational neuroscience research. Here, we evaluate the effects of a 24-h melatonin treatment on behavior and physiology of adult zebrafish with circadian rhythm disturbed by a 24-h light exposure. While such light exposure evoked overt cognitive and neuroendocrine (cortisol) deficits in zebrafish, these effects were reversed by a 24-h melatonin treatment. Collectively, these findings suggest a positive modulation of affective and cognitive phenotypes in zebrafish by melatonin, and reinforce the growing utility of zebrafish models for studying circadian, cognitive and behavioral processes and their neuroendocrine regulation in vivo.

KW - Cognition

KW - Cortisol

KW - Light cycle

KW - Melatonin

KW - Zebrafish

KW - EFFICACY

KW - DYSFUNCTIONS

KW - CIRCADIAN-RHYTHMS

KW - SLEEP-DEPRIVATION

KW - CHRONIC MILD STRESS

KW - SCOPOLAMINE

KW - MODEL

KW - ANXIETY-LIKE BEHAVIOR

KW - INDUCED MEMORY IMPAIRMENT

KW - LIVER-ENZYMES

UR - http://www.scopus.com/inward/record.url?scp=85085569283&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2020.135073

DO - 10.1016/j.neulet.2020.135073

M3 - Article

C2 - 32446774

AN - SCOPUS:85085569283

VL - 733

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

M1 - 135073

ER -

ID: 53907333