Abstract: The capacity of comprehensive standardized stepped medical rehabilitation is assessed in 469 patients who underwent surgical procedures for severe craniocerebral injury in Saint Petersburg hospitals in 2010–2017. As a result of the neurorehabilitation system, the incidence rates of infectious and inflammatory complications associated with physical inactivity significantly declined. The average number of bed days decreased from 34 ± 5 to 23 ± 4 days. At the time of discharge from the neurosurgical hospital, the Barthel index (BI) of activities of daily living (ADL) was 42 ± 8 points. After inpatient rehabilitation, the average BI score improved to 70 ± 6 points. The subsequent course of therapy through the outpatient rehabilitation resulted in the average BI score increase to 78 ± 6 points.