Research output: Contribution to journal › Article › peer-review
Maternal serum nitrotyrosine, 8-isoprostane and total antioxidant capacity levels in pre-gestational or gestational diabetes mellitus. / Kapustin, Roman; Chepanov, Sergey; Kopteeva, Ekaterina; Arzhanova, Olga.
In: Gynecological Endocrinology, Vol. 36, No. S1, 2020, p. 36-42.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Maternal serum nitrotyrosine, 8-isoprostane and total antioxidant capacity levels in pre-gestational or gestational diabetes mellitus
AU - Kapustin, Roman
AU - Chepanov, Sergey
AU - Kopteeva, Ekaterina
AU - Arzhanova, Olga
N1 - Publisher Copyright: © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the UR MED GRUPP (LLC).
PY - 2020
Y1 - 2020
N2 - Objective: To evaluate serum concentration of 8-isoprostane, nitrotyrosine (NT), and total antioxidant capacity (TAC) in pregnant women with diabetes mellitus (DM) considering preconception planning and method of diabetes correction in 11–14 and 30–34 weeks. Materials and methods: The study included 130 women: T1DM (n = 40), T2DM (n = 35), gestational diabetes (GDM, n = 40) and the control group (n = 15). The serum concentrations of NT, 8-isoprostane, and TAC were measured by ELISA methods. Results: Elevated 8-isoprostane levels were observed in all patients with DM, but this biomarker's maximum values have been seen in T1DM and T2DM on insulin groups. A similar tendency was observed for the concentration of NT in both the 1st and 3rd trimesters. TAC levels showed a statistically relevant decrease in all DM groups compared to the control. The correlation analysis showed a direct correlation between HbA1c and serum 8-isoprostane levels in the 1st (r =.27) and 3rd (r =.3) pregnancy trimesters as well as inverse correlation with TAC level (r = −.48). Direct (NT, 8-isoprostane) and inverse correlations (TAC) were fixated for this biomarker concentration and preeclampsia rates. Conclusion: DM in pregnancy is related to oxidative stress activation, which might lead to the development of adverse perinatal outcomes.
AB - Objective: To evaluate serum concentration of 8-isoprostane, nitrotyrosine (NT), and total antioxidant capacity (TAC) in pregnant women with diabetes mellitus (DM) considering preconception planning and method of diabetes correction in 11–14 and 30–34 weeks. Materials and methods: The study included 130 women: T1DM (n = 40), T2DM (n = 35), gestational diabetes (GDM, n = 40) and the control group (n = 15). The serum concentrations of NT, 8-isoprostane, and TAC were measured by ELISA methods. Results: Elevated 8-isoprostane levels were observed in all patients with DM, but this biomarker's maximum values have been seen in T1DM and T2DM on insulin groups. A similar tendency was observed for the concentration of NT in both the 1st and 3rd trimesters. TAC levels showed a statistically relevant decrease in all DM groups compared to the control. The correlation analysis showed a direct correlation between HbA1c and serum 8-isoprostane levels in the 1st (r =.27) and 3rd (r =.3) pregnancy trimesters as well as inverse correlation with TAC level (r = −.48). Direct (NT, 8-isoprostane) and inverse correlations (TAC) were fixated for this biomarker concentration and preeclampsia rates. Conclusion: DM in pregnancy is related to oxidative stress activation, which might lead to the development of adverse perinatal outcomes.
KW - 8-isoprostane
KW - diabetes mellitus
KW - gestational diabetes
KW - nitrotyrosine
KW - preeclampsia
KW - pregnancy
KW - total antioxidant capacity
UR - http://www.scopus.com/inward/record.url?scp=85097501441&partnerID=8YFLogxK
U2 - 10.1080/09513590.2020.1816727
DO - 10.1080/09513590.2020.1816727
M3 - Article
C2 - 33305672
AN - SCOPUS:85097501441
VL - 36
SP - 36
EP - 42
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
SN - 0951-3590
IS - S1
ER -
ID: 85957005