Research output: Contribution to journal › Article › peer-review
Mast cells and aging. / Kutukova, N. A.; Nazarov, P. G.; Kudryavtseva, G. V.; Shishkin, V. I.
In: Advances in Gerontology (Uspekhi Gerontologii), Vol. 7, No. 1, 01.01.2017, p. 68-75.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Mast cells and aging
AU - Kutukova, N. A.
AU - Nazarov, P. G.
AU - Kudryavtseva, G. V.
AU - Shishkin, V. I.
N1 - Publisher Copyright: © 2017, Pleiades Publishing, Ltd. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Mast cells (MCs) are present in the skin and mucous membranes, lymphoid organs, intestine wall, and brain, where they are located close to blood and lymphatic vessels and nerve terminals. As a source of a large number of biologically active substances, many of which are released quickly into the environment as a result of degranulation process, mast cells play an essential role in the regulation of physiological processes in the tissues where they are present. Changes in the MC population and activity in tissues during aging is associated with age-related changes of the skin and mucous membranes, as well as the development of centralnervous- system disorders such as itching, headache, joint and muscle pain, memory loss, attention deficit, depression, anxiety and depressive disorders, autism, Alzheimer’s disease, and multiple sclerosis.
AB - Mast cells (MCs) are present in the skin and mucous membranes, lymphoid organs, intestine wall, and brain, where they are located close to blood and lymphatic vessels and nerve terminals. As a source of a large number of biologically active substances, many of which are released quickly into the environment as a result of degranulation process, mast cells play an essential role in the regulation of physiological processes in the tissues where they are present. Changes in the MC population and activity in tissues during aging is associated with age-related changes of the skin and mucous membranes, as well as the development of centralnervous- system disorders such as itching, headache, joint and muscle pain, memory loss, attention deficit, depression, anxiety and depressive disorders, autism, Alzheimer’s disease, and multiple sclerosis.
KW - aging
KW - blood vessels
KW - mast cells
KW - mediators
KW - nerve terminals
KW - nervous-system disorders
UR - http://www.scopus.com/inward/record.url?scp=85017527104&partnerID=8YFLogxK
U2 - 10.1134/S207905701701009X
DO - 10.1134/S207905701701009X
M3 - Article
AN - SCOPUS:85017527104
VL - 7
SP - 68
EP - 75
JO - Advances in Gerontology
JF - Advances in Gerontology
SN - 2079-0570
IS - 1
ER -
ID: 9214418