TY - JOUR

T1 - Magnetically controlled carbonate nanocomposite with ciprofloxacin for biofilm eradication

AU - Rumyantceva, Viktoriya

AU - Rumyantceva, Valeriya

AU - Andreeva, Yulia

AU - Tsvetikova, Sofia

AU - Radaev, Anton

AU - Vishnevskaya, Maria

AU - Vinogradov, Vladimir

AU - Drozdov, Andrey S.

AU - Koshel, Elena

N1 - Rumyantceva V, Rumyantceva V, Andreeva Y, Tsvetikova S, Radaev A, Vishnevskaya M, Vinogradov V, Drozdov AS, Koshel E. Magnetically Controlled Carbonate Nanocomposite with Ciprofloxacin for Biofilm Eradication. International Journal of Molecular Sciences. 2021; 22(12):6187. https://doi.org/10.3390/ijms22126187

PY - 2021/6/8

Y1 - 2021/6/8

N2 - Biofilms are the reason for a vast majority of chronic inflammation cases and most acute inflammation. The treatment of biofilms still is a complicated task due to the low efficiency of drug delivery and high resistivity of the involved bacteria to harmful factors. Here we describe a magnetically controlled nanocomposite with a stimuli-responsive release profile based on calcium carbonate and magnetite with an encapsulated antibiotic (ciprofloxacin) that can be used to solve this problem. The material magnetic properties allowed targeted delivery, accumulation, and penetration of the composite in the biofilm, as well as the rapid triggered release of the entrapped antibiotic. Under the influence of an RF magnetic field with a frequency of 210 kHz, the composite underwent a phase transition from vaterite into calcite and promoted the release of ciprofloxacin. The effectiveness of the composite was tested against formed biofilms of E. coli and S. aureus and showed a 71% reduction in E. coli biofilm biomass and an 85% reduction in S. aureus biofilms. The efficiency of the composite with entrapped ciprofloxacin was higher than for the free antibiotic in the same concentration, up to 72%. The developed composite is a promising material for the treatment of biofilm-associated inflammations.

AB - Biofilms are the reason for a vast majority of chronic inflammation cases and most acute inflammation. The treatment of biofilms still is a complicated task due to the low efficiency of drug delivery and high resistivity of the involved bacteria to harmful factors. Here we describe a magnetically controlled nanocomposite with a stimuli-responsive release profile based on calcium carbonate and magnetite with an encapsulated antibiotic (ciprofloxacin) that can be used to solve this problem. The material magnetic properties allowed targeted delivery, accumulation, and penetration of the composite in the biofilm, as well as the rapid triggered release of the entrapped antibiotic. Under the influence of an RF magnetic field with a frequency of 210 kHz, the composite underwent a phase transition from vaterite into calcite and promoted the release of ciprofloxacin. The effectiveness of the composite was tested against formed biofilms of E. coli and S. aureus and showed a 71% reduction in E. coli biofilm biomass and an 85% reduction in S. aureus biofilms. The efficiency of the composite with entrapped ciprofloxacin was higher than for the free antibiotic in the same concentration, up to 72%. The developed composite is a promising material for the treatment of biofilm-associated inflammations.

KW - Antibiotic

KW - Antimicrobial effect

KW - Biofilm

KW - Magnetite

KW - Nanocomposite

KW - antibiotic

KW - IRON-OXIDE NANOPARTICLES

KW - magnetite

KW - DIAGNOSIS

KW - INFECTIONS

KW - ANTIBIOTICS

KW - EFFICACY

KW - antimicrobial effect

KW - ALKALINE PH

KW - BACTERIAL BIOFILMS

KW - CALCIUM-CARBONATE

KW - DELIVERY

KW - PSEUDOMONAS-AERUGINOSA

KW - biofilm

KW - nanocomposite

UR - http://www.scopus.com/inward/record.url?scp=85107332070&partnerID=8YFLogxK

U2 - 10.3390/ijms22126187

DO - 10.3390/ijms22126187

M3 - Article

AN - SCOPUS:85107332070

VL - 22

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 12

M1 - 6187

ER -