Objectives: The management of severe coronary artery disease at the time of lung transplantation remains a challenge. We analyzed the short- and long-term-outcomes of lung transplant recipients with severe coronary artery disease.

Methods: Records of adult patients transplanted at our institution between April 2010 and February 2021 were retrospectively reviewed. Severe coronary artery disease was defined by coronary stenosis ≥70% (main stem ≥50%) at the coronary angiography performed before or at the time of listing. Patient characteristics, perioperative- and long-term-outcomes were compared between patients with and without severe coronary artery disease.

Results: Among 896 lung-transplanted patients who had undergone a coronary angiography before transplantation, 77 (8.5%) showed severe coronary artery disease, the remaining 819 (91.5%) did not. Patients with severe coronary artery disease were older (p < 0.0001), more often male (p < 0.0001) and were transplanted more often for pulmonary fibrosis (p = 0.0007). The median (interquartile range) follow-up was 46 (20-76) months. At the Cox multivariable analysis severe coronary artery disease was not associated with mortality. Patients with pretransplant percutaneous transluminal coronary angioplasty and patients with coronary artery bypass graft surgery concomitant to transplantation had equivalent survival compared to patients without severe coronary artery disease (p = 0.513, p = 0.556).

Conclusions: Severe coronary artery disease was not associated with decreased survival after lung transplantation. Concomitant coronary artery bypass graft surgery and pretransplant percutaneous transluminal coronary angioplasty can be used for revascularization.