TY - JOUR

T1 - Long-Range Temporal Correlations in the amplitude of alpha oscillations predict and reflect strength of intracortical facilitation

T2 - Combined TMS and EEG study

AU - Fedele, Tommaso

AU - Blagovechtchenski, Evgeny

AU - Nazarova, Maria

AU - Iscan, Zafer

AU - Moiseeva, Victoria

AU - Nikulin, Vadim V.

N1 - Publisher Copyright: © 2016 IBRO

PY - 2016/9/7

Y1 - 2016/9/7

N2 - While variability of the motor responses to transcranial magnetic stimulation (TMS) is widely acknowledged, little is known about its central origin. One plausible explanation for such variability may relate to different neuronal states defining the reactivity of the cortex to TMS. In this study intrinsic spatio-temporal neuronal dynamics were estimated with Long-Range Temporal Correlations (LRTC) in order to predict the inter-individual differences in the strength of intra-cortical facilitation (ICF) and short-interval intracortical inhibition (SICI) produced by paired-pulse TMS (ppTMS) of the left primary motor cortex. LRTC in the alpha frequency range were assessed from multichannel electroencephalography (EEG) obtained at rest before and after the application of and single-pulse TMS (spTMS) and ppTMS protocols. For the EEG session, preceding TMS application, we showed a positive correlation across subjects between the strength of ICF and LRTC in the fronto-central and parietal areas. This in turn attests to the existence of subject-specific neuronal phenotypes defining the reactivity of the brain to ppTMS. In addition, we also showed that ICF was associated with the changes in neuronal dynamics in the EEG session after the application of the stimulation. This result provides a complementary evidence for the recent findings demonstrating that the cortical stimulation with sparse non-regular stimuli might have considerable long-lasting effects on the cortical activity.

AB - While variability of the motor responses to transcranial magnetic stimulation (TMS) is widely acknowledged, little is known about its central origin. One plausible explanation for such variability may relate to different neuronal states defining the reactivity of the cortex to TMS. In this study intrinsic spatio-temporal neuronal dynamics were estimated with Long-Range Temporal Correlations (LRTC) in order to predict the inter-individual differences in the strength of intra-cortical facilitation (ICF) and short-interval intracortical inhibition (SICI) produced by paired-pulse TMS (ppTMS) of the left primary motor cortex. LRTC in the alpha frequency range were assessed from multichannel electroencephalography (EEG) obtained at rest before and after the application of and single-pulse TMS (spTMS) and ppTMS protocols. For the EEG session, preceding TMS application, we showed a positive correlation across subjects between the strength of ICF and LRTC in the fronto-central and parietal areas. This in turn attests to the existence of subject-specific neuronal phenotypes defining the reactivity of the brain to ppTMS. In addition, we also showed that ICF was associated with the changes in neuronal dynamics in the EEG session after the application of the stimulation. This result provides a complementary evidence for the recent findings demonstrating that the cortical stimulation with sparse non-regular stimuli might have considerable long-lasting effects on the cortical activity.

KW - EEG

KW - motor cortex

KW - neuronal dynamics

KW - neuronal oscillations

KW - TMS

KW - variability

UR - http://www.scopus.com/inward/record.url?scp=84976556383&partnerID=8YFLogxK

U2 - 10.1016/j.neuroscience.2016.06.015

DO - 10.1016/j.neuroscience.2016.06.015

M3 - Article

C2 - 27318302

AN - SCOPUS:84976556383

VL - 331

SP - 109

EP - 119

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -