Lipoxygenases modulate the effect of glutoxim on Na+ transport in the frog skin epithelium

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Lipoxygenases modulate the effect of glutoxim on Na+ transport in the frog skin epithelium. / Krutetskaya, Z. I. ; Melnitskaya, A. V. ; Antonov, V. G. ; Nozdrachev, A. D. .

In: Doklady Biochemistry and Biophysics, Vol. 474, No. 1, 2017, p. 193-195.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{87eb5fe2d226402a97bc67b6f8ef0de1,

title = "Lipoxygenases modulate the effect of glutoxim on Na+ transport in the frog skin epithelium",

abstract = "Using voltage-clamp technique, the involvement of lipoxygenases in the effect of immunomodulatory drug glutoxim on Na+ transport in frog skin was investigated. It was shown for the first time that preincubation of the skin with lipoxygenase inhibitors caffeic acid, baicalein, and nordihydroguaiaretic acid significantly decreases the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of lipoxygenase oxidation pathway of arachidonic acid metabolism in the glutoxim effect on Na+ transport in frog skin epithelium.",

keywords = " glutoxim, Na+ transport, frog skin, lipoxygenases ",

author = "Krutetskaya, {Z. I.} and Melnitskaya, {A. V.} and Antonov, {V. G.} and Nozdrachev, {A. D.}",

note = "Krutetskaya, Z.I., Melnitskaya, A.V., Antonov, V.G. et al. Lipoxygenases modulate the effect of glutoxim on Na+ transport in the frog skin epithelium. Dokl Biochem Biophys 474, 193–195 (2017). https://doi.org/10.1134/S1607672917030073",

year = "2017",

language = "English",

volume = "474",

pages = "193--195",

journal = "Doklady Biochemistry and Biophysics",

issn = "1607-6729",

publisher = "МАИК {"}Наука/Интерпериодика{"}",

number = "1",

}

RIS

TY - JOUR

T1 - Lipoxygenases modulate the effect of glutoxim on Na+ transport in the frog skin epithelium

AU - Krutetskaya, Z. I.

AU - Melnitskaya, A. V.

AU - Antonov, V. G.

AU - Nozdrachev, A. D.

N1 - Krutetskaya, Z.I., Melnitskaya, A.V., Antonov, V.G. et al. Lipoxygenases modulate the effect of glutoxim on Na+ transport in the frog skin epithelium. Dokl Biochem Biophys 474, 193–195 (2017). https://doi.org/10.1134/S1607672917030073

PY - 2017

Y1 - 2017

N2 - Using voltage-clamp technique, the involvement of lipoxygenases in the effect of immunomodulatory drug glutoxim on Na+ transport in frog skin was investigated. It was shown for the first time that preincubation of the skin with lipoxygenase inhibitors caffeic acid, baicalein, and nordihydroguaiaretic acid significantly decreases the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of lipoxygenase oxidation pathway of arachidonic acid metabolism in the glutoxim effect on Na+ transport in frog skin epithelium.

AB - Using voltage-clamp technique, the involvement of lipoxygenases in the effect of immunomodulatory drug glutoxim on Na+ transport in frog skin was investigated. It was shown for the first time that preincubation of the skin with lipoxygenase inhibitors caffeic acid, baicalein, and nordihydroguaiaretic acid significantly decreases the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of lipoxygenase oxidation pathway of arachidonic acid metabolism in the glutoxim effect on Na+ transport in frog skin epithelium.

KW - glutoxim, Na+ transport, frog skin, lipoxygenases

UR - https://link.springer.com/article/10.1134/S1607672917030073

M3 - Article

VL - 474

SP - 193

EP - 195

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

ER -

ID: 9353258