Research output: Contribution to journal › Article › peer-review
Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads. / Krasavin, Mikhail; Mujumdar, Prashant; Parchinsky, Vladislav; Vinogradova, Tatiana; Manicheva, Olga; Dogonadze, Marine.
In: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 31, No. 6, 01.11.2016, p. 1146-1155.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads
AU - Krasavin, Mikhail
AU - Mujumdar, Prashant
AU - Parchinsky, Vladislav
AU - Vinogradova, Tatiana
AU - Manicheva, Olga
AU - Dogonadze, Marine
PY - 2016/11/1
Y1 - 2016/11/1
N2 - A novel library based on quinolin-4-ylimidazoline core was designed to incorporate a general quinoline antimicrobial pharmacophore. A synthesis of the well-characterized library of 36 compounds was achieved using the Pd-catalyzed Buchwald–Hartwig-type imidazoline arylation chemistry developed earlier. Compounds were tested for biological activity and were found to possess no antimalarial activity. However, the library delivered two promising antitubercular leads, which are non-cytotoxic and can be further optimized with respect to antimycobacterial potency.
AB - A novel library based on quinolin-4-ylimidazoline core was designed to incorporate a general quinoline antimicrobial pharmacophore. A synthesis of the well-characterized library of 36 compounds was achieved using the Pd-catalyzed Buchwald–Hartwig-type imidazoline arylation chemistry developed earlier. Compounds were tested for biological activity and were found to possess no antimalarial activity. However, the library delivered two promising antitubercular leads, which are non-cytotoxic and can be further optimized with respect to antimycobacterial potency.
KW - 2-imidazoline
KW - Antimalarial
KW - antitubercular
KW - Buchwald–Hartwig
KW - microwave chemistry
KW - non-cytotoxic
KW - quinoline
UR - http://www.scopus.com/inward/record.url?scp=84989298235&partnerID=8YFLogxK
U2 - 10.3109/14756366.2015.1101094
DO - 10.3109/14756366.2015.1101094
M3 - Article
C2 - 26526717
AN - SCOPUS:84989298235
VL - 31
SP - 1146
EP - 1155
JO - Journal of Enzyme Inhibition and Medicinal Chemistry
JF - Journal of Enzyme Inhibition and Medicinal Chemistry
SN - 1475-6366
IS - 6
ER -
ID: 26202191