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Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads. / Krasavin, Mikhail; Mujumdar, Prashant; Parchinsky, Vladislav; Vinogradova, Tatiana; Manicheva, Olga; Dogonadze, Marine.

In: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 31, No. 6, 01.11.2016, p. 1146-1155.

Research output: Contribution to journalArticlepeer-review

Harvard

Krasavin, M, Mujumdar, P, Parchinsky, V, Vinogradova, T, Manicheva, O & Dogonadze, M 2016, 'Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads', Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 31, no. 6, pp. 1146-1155. https://doi.org/10.3109/14756366.2015.1101094

APA

Krasavin, M., Mujumdar, P., Parchinsky, V., Vinogradova, T., Manicheva, O., & Dogonadze, M. (2016). Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), 1146-1155. https://doi.org/10.3109/14756366.2015.1101094

Vancouver

Krasavin M, Mujumdar P, Parchinsky V, Vinogradova T, Manicheva O, Dogonadze M. Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads. Journal of Enzyme Inhibition and Medicinal Chemistry. 2016 Nov 1;31(6):1146-1155. https://doi.org/10.3109/14756366.2015.1101094

Author

Krasavin, Mikhail ; Mujumdar, Prashant ; Parchinsky, Vladislav ; Vinogradova, Tatiana ; Manicheva, Olga ; Dogonadze, Marine. / Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads. In: Journal of Enzyme Inhibition and Medicinal Chemistry. 2016 ; Vol. 31, No. 6. pp. 1146-1155.

BibTeX

@article{3f31396e8b68455a92eda433362c3261,
title = "Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads",
abstract = "A novel library based on quinolin-4-ylimidazoline core was designed to incorporate a general quinoline antimicrobial pharmacophore. A synthesis of the well-characterized library of 36 compounds was achieved using the Pd-catalyzed Buchwald–Hartwig-type imidazoline arylation chemistry developed earlier. Compounds were tested for biological activity and were found to possess no antimalarial activity. However, the library delivered two promising antitubercular leads, which are non-cytotoxic and can be further optimized with respect to antimycobacterial potency.",
keywords = "2-imidazoline, Antimalarial, antitubercular, Buchwald–Hartwig, microwave chemistry, non-cytotoxic, quinoline",
author = "Mikhail Krasavin and Prashant Mujumdar and Vladislav Parchinsky and Tatiana Vinogradova and Olga Manicheva and Marine Dogonadze",
year = "2016",
month = nov,
day = "1",
doi = "10.3109/14756366.2015.1101094",
language = "English",
volume = "31",
pages = "1146--1155",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
issn = "1475-6366",
publisher = "Taylor & Francis",
number = "6",

}

RIS

TY - JOUR

T1 - Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads

AU - Krasavin, Mikhail

AU - Mujumdar, Prashant

AU - Parchinsky, Vladislav

AU - Vinogradova, Tatiana

AU - Manicheva, Olga

AU - Dogonadze, Marine

PY - 2016/11/1

Y1 - 2016/11/1

N2 - A novel library based on quinolin-4-ylimidazoline core was designed to incorporate a general quinoline antimicrobial pharmacophore. A synthesis of the well-characterized library of 36 compounds was achieved using the Pd-catalyzed Buchwald–Hartwig-type imidazoline arylation chemistry developed earlier. Compounds were tested for biological activity and were found to possess no antimalarial activity. However, the library delivered two promising antitubercular leads, which are non-cytotoxic and can be further optimized with respect to antimycobacterial potency.

AB - A novel library based on quinolin-4-ylimidazoline core was designed to incorporate a general quinoline antimicrobial pharmacophore. A synthesis of the well-characterized library of 36 compounds was achieved using the Pd-catalyzed Buchwald–Hartwig-type imidazoline arylation chemistry developed earlier. Compounds were tested for biological activity and were found to possess no antimalarial activity. However, the library delivered two promising antitubercular leads, which are non-cytotoxic and can be further optimized with respect to antimycobacterial potency.

KW - 2-imidazoline

KW - Antimalarial

KW - antitubercular

KW - Buchwald–Hartwig

KW - microwave chemistry

KW - non-cytotoxic

KW - quinoline

UR - http://www.scopus.com/inward/record.url?scp=84989298235&partnerID=8YFLogxK

U2 - 10.3109/14756366.2015.1101094

DO - 10.3109/14756366.2015.1101094

M3 - Article

C2 - 26526717

AN - SCOPUS:84989298235

VL - 31

SP - 1146

EP - 1155

JO - Journal of Enzyme Inhibition and Medicinal Chemistry

JF - Journal of Enzyme Inhibition and Medicinal Chemistry

SN - 1475-6366

IS - 6

ER -

ID: 26202191