Research output: Contribution to journal › Article › peer-review
Wide concentration range (10(-14)-10(-4) M) of bis-(n-tributyltin)-oxide effect on Na(+)-dependent uptake, spontaneous and K(+)-stimulated release, specific receptor binding and GABA metabolism were studied in vitro experiments using brain slices, synaptic membrane fraction and brain tissue homogenates. It is shown that the dependence "concentration-effect" is of non-linear character in all cases. Prevailing suppression of Na(+)-dependent uptake and specific receptor binding during K(+)-stimulated release and metabolism (production and utilization) of GABA activation were marked as a general tendency. Mechanisms of TBTO effect on the studied processes and the involvement of GABA-ergic system in realization of TBTO neurotoxic effects are discussed.
Translated title of the contribution | Effect of bis(n-tributyltin)-oxide on the brain GABA-ergic system in vitro |
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Original language | Russian |
Pages (from-to) | 71-79 |
Number of pages | 9 |
Journal | Ukrainskii biokhimicheskii zhurnal |
Volume | 66 |
Issue number | 2 |
State | Published - 1 Mar 1994 |
ID: 42768788