Research output: Contribution to journal › Review article › peer-review
Isotretinoin : Efficacy and safety (literature review). / Smirnova, I. O.; Petunova, Ya G.; Kulikova, E. A.; Eremeeva, A. S.
In: Klinicheskaya Dermatologiya i Venerologiya, Vol. 14, No. 6, 2015, p. 20-27.Research output: Contribution to journal › Review article › peer-review
}
TY - JOUR
T1 - Isotretinoin
T2 - Efficacy and safety (literature review)
AU - Smirnova, I. O.
AU - Petunova, Ya G.
AU - Kulikova, E. A.
AU - Eremeeva, A. S.
N1 - Publisher Copyright: © 2015, Media Sphera Publishing Group. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Isotretinoin is one of the most effective drugs to treat patients with severe acne. However, there are some unsolved issues related to its administration. This applies to selection of an adequate dose of the drug, its safety, and stability of disease remission after treatment. The objective of this work was to analyze the literature on the choice of the optimal daily and cumulative dose of isotretinoin, the incidence and causes of relapses of acne after comprehensive treatment, the structure and incidence of the most significant side effects. Material and Methods. We analysed 59 literature sources. The following keywords were used as search criteria: «isotretinoin», «acne», «efficacy», «mechanisms of action», «side effects», «teratogenicity», «depression», «inflammatory intestinal diseases». Conclusion. Isotretinoin have been used for over 30 years, which conclusively proves its high clinical efficacy in treatment of patients with severe acne. However, the data accumulated so far show that some patients have relapses of the disease after the complete course of treatment. Potential complications, some of which appears to be very significant (depression, inflammatory intestinal diseases, etc.) may also significantly limit the use of the drug in clinical practice.
AB - Isotretinoin is one of the most effective drugs to treat patients with severe acne. However, there are some unsolved issues related to its administration. This applies to selection of an adequate dose of the drug, its safety, and stability of disease remission after treatment. The objective of this work was to analyze the literature on the choice of the optimal daily and cumulative dose of isotretinoin, the incidence and causes of relapses of acne after comprehensive treatment, the structure and incidence of the most significant side effects. Material and Methods. We analysed 59 literature sources. The following keywords were used as search criteria: «isotretinoin», «acne», «efficacy», «mechanisms of action», «side effects», «teratogenicity», «depression», «inflammatory intestinal diseases». Conclusion. Isotretinoin have been used for over 30 years, which conclusively proves its high clinical efficacy in treatment of patients with severe acne. However, the data accumulated so far show that some patients have relapses of the disease after the complete course of treatment. Potential complications, some of which appears to be very significant (depression, inflammatory intestinal diseases, etc.) may also significantly limit the use of the drug in clinical practice.
KW - Acne treatment
KW - Efficacy
KW - Isotretinoin
KW - Safety
KW - Side effects
UR - http://www.scopus.com/inward/record.url?scp=85096650532&partnerID=8YFLogxK
U2 - 10.17116/klinderma201514620-27
DO - 10.17116/klinderma201514620-27
M3 - Review article
AN - SCOPUS:85096650532
VL - 14
SP - 20
EP - 27
JO - КЛИНИЧЕСКАЯ ДЕРМАТОЛОГИЯ И ВЕНЕРОЛОГИЯ
JF - КЛИНИЧЕСКАЯ ДЕРМАТОЛОГИЯ И ВЕНЕРОЛОГИЯ
SN - 1997-2849
IS - 6
ER -
ID: 92570646