Research output: Contribution to journal › Article › peer-review
“Isocyanide-less” Ugi/Intramolecular Diels-Alder reaction of 5-hydroxymethylfurfural. / Golubev, Pavel; Pankova, Alena; Krasavin, Mikhail.
In: Tetrahedron Letters, Vol. 60, No. 24, 13.06.2019, p. 1578-1581.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - “Isocyanide-less” Ugi/Intramolecular Diels-Alder reaction of 5-hydroxymethylfurfural
AU - Golubev, Pavel
AU - Pankova, Alena
AU - Krasavin, Mikhail
PY - 2019/6/13
Y1 - 2019/6/13
N2 - The one-pot, three-step, four-component Ugi-IMDAF reaction with 5-hydroxymethylfurfural provides simple access to hydroxymethyl-substituted epoxyisoindolones in a diastereoselective and stereospecific manner. The protocol avoids the transfer or isolation of isocyanides, and the broad scope was illustrated by the synthesis of 22 different compounds bearing various substituents on the heterocyclic core.
AB - The one-pot, three-step, four-component Ugi-IMDAF reaction with 5-hydroxymethylfurfural provides simple access to hydroxymethyl-substituted epoxyisoindolones in a diastereoselective and stereospecific manner. The protocol avoids the transfer or isolation of isocyanides, and the broad scope was illustrated by the synthesis of 22 different compounds bearing various substituents on the heterocyclic core.
KW - 5-Hydroxymethylfurfural
KW - Diels-Alder reaction
KW - Isocyanide-based multicomponent reaction
KW - Ugi reaction
KW - PRODUCTS
KW - TRICYCLIC NITROGEN-HETEROCYCLES
KW - UGI REACTION
KW - SKELETAL
UR - http://www.scopus.com/inward/record.url?scp=85065922864&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/isocyanideless-ugiintramolecular-dielsalder-reaction-5hydroxymethylfurfural
U2 - 10.1016/j.tetlet.2019.05.018
DO - 10.1016/j.tetlet.2019.05.018
M3 - Article
AN - SCOPUS:85065922864
VL - 60
SP - 1578
EP - 1581
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 24
ER -
ID: 49034575