Research output: Contribution to journal › Article › peer-review
Involvement of Microtubules in the Glutoxim Regulation of Na+ Transport in the Frog Skin. / Krutetskaya, Z. I.; Mel’nitskaya, A. V.; Antonov, V. G.; Nozdrachev, A. D.
In: Doklady Biological Sciences, Vol. 445, No. 1, 2012, p. 227-229.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Involvement of Microtubules in the Glutoxim Regulation of Na+ Transport in the Frog Skin
AU - Krutetskaya, Z. I.
AU - Mel’nitskaya, A. V.
AU - Antonov, V. G.
AU - Nozdrachev, A. D.
PY - 2012
Y1 - 2012
N2 - The amphibian skin and other isolated epithelial systems are classical model objects for studying the mechanisms of transepithelial ion transport. In their ability to transport electrolytes and in response to some hormones, the amphibian skin and bladder are similar to the distal renal tubules [1]; this allows the data for these model objects to be used for clarifying the mechanisms of water and ion transports in renal cells. The Na+ transport in osmoregulatory epithelia is a complex multicomponent system providing the establishment and maintenance of electrolytic and water homeostasis. The key sodium transport proteins, such as amiloride-sensitive epithelial Na+ channels (ENaCs), Na+/K+ ATPases, and Na+/H+ exchangers, are targets for oxidative stress [2]. However, the mechanisms underlying the effect of oxidants and reducing agents on individual components of the Na+ transepithelial transport are still unknown.
AB - The amphibian skin and other isolated epithelial systems are classical model objects for studying the mechanisms of transepithelial ion transport. In their ability to transport electrolytes and in response to some hormones, the amphibian skin and bladder are similar to the distal renal tubules [1]; this allows the data for these model objects to be used for clarifying the mechanisms of water and ion transports in renal cells. The Na+ transport in osmoregulatory epithelia is a complex multicomponent system providing the establishment and maintenance of electrolytic and water homeostasis. The key sodium transport proteins, such as amiloride-sensitive epithelial Na+ channels (ENaCs), Na+/K+ ATPases, and Na+/H+ exchangers, are targets for oxidative stress [2]. However, the mechanisms underlying the effect of oxidants and reducing agents on individual components of the Na+ transepithelial transport are still unknown.
U2 - 10.1134/S0012496612040205
DO - 10.1134/S0012496612040205
M3 - статья
VL - 445
SP - 227
EP - 229
JO - Doklady Biological Sciences
JF - Doklady Biological Sciences
SN - 0012-4966
IS - 1
ER -
ID: 5379460