Inter-Strain Differences in the Lumbar Spinal Cord Anatomy and Neuromorphology: Wistar Versus Dark Agouti Rats

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Inter-Strain Differences in the Lumbar Spinal Cord Anatomy and Neuromorphology: Wistar Versus Dark Agouti Rats. / Veshchitskii, A.; Shkorbatova, P.; Efimova, E.; Merkulyeva, N.

In: Journal of Comparative Neurology, Vol. 532, No. 10, 01.10.2024.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{00e53fce66c74dbfa60b54f860febd53,

title = "Inter-Strain Differences in the Lumbar Spinal Cord Anatomy and Neuromorphology: Wistar Versus Dark Agouti Rats",

abstract = "Rat strains differ in physiology, behavior, and recovery after central nervous system injury. To assess these differences, we compared the gross and local anatomy and neuromorphology of the lumbar spinal cord of the Wistar and Dark Agouti (DA) strains. The key findings include (i) distinct spatial relationships between vertebrae and spinal segments in the two strains; (ii) Wistar rats have larger volumes of spinal cord gray and white matter; (iii) DA rats have smaller total neuronal populations, thus indicating an expectation of smaller local neuronal populations; (iv) this expectation was confirmed for interneurons expressing calbindin 28 kDa. But contrary to expectations, (v) DA rats had more numerous populations of the interneurons expressing parvalbumin and a population of α-motoneurons. Consequently, these strains displayed divergent ratios in specific spinal neuronal populations. Researchers should consider these inter-strain differences when comparing data across different strains. {\textcopyright} 2024 Wiley Periodicals LLC.",

keywords = "calbindin, Dark Agouti, inter-strain differences, parvalbumin, spinal cord, Wistar, α-motoneurons, alpha nerve fiber, Article, cell population, controlled study, dark agouti rat, gray matter, gross anatomy, interneuron, lumbar spinal cord, lumbar spine, male, neuroanatomy, nonhuman, protein expression, rat, rat strain, strain difference, strain identification, white matter, Wistar rat, animal, cytology, lumbar vertebra, metabolism, nerve cell, species difference, Animals, Lumbar Vertebrae, Male, Neurons, Rats, Rats, Wistar, Species Specificity, Spinal Cord",

author = "A. Veshchitskii and P. Shkorbatova and E. Efimova and N. Merkulyeva",

note = "Export Date: 21 October 2024 CODEN: JCNEA Адрес для корреспонденции: Merkulyeva, N.; Pavlov Institute of Physiology Russian Academy of SciencesRussian Federation; эл. почта: merkulyevan@infran.ru Химические вещества/CAS: parvalbumin, 56094-12-3, 83667-75-8",

year = "2024",

month = oct,

day = "1",

doi = "10.1002/cne.25673",

language = "Английский",

volume = "532",

journal = "Journal of Comparative Neurology",

issn = "0021-9967",

publisher = "Wiley-Blackwell",

number = "10",

}

RIS

TY - JOUR

T1 - Inter-Strain Differences in the Lumbar Spinal Cord Anatomy and Neuromorphology: Wistar Versus Dark Agouti Rats

AU - Veshchitskii, A.

AU - Shkorbatova, P.

AU - Efimova, E.

AU - Merkulyeva, N.

N1 - Export Date: 21 October 2024 CODEN: JCNEA Адрес для корреспонденции: Merkulyeva, N.; Pavlov Institute of Physiology Russian Academy of SciencesRussian Federation; эл. почта: merkulyevan@infran.ru Химические вещества/CAS: parvalbumin, 56094-12-3, 83667-75-8

PY - 2024/10/1

Y1 - 2024/10/1

N2 - Rat strains differ in physiology, behavior, and recovery after central nervous system injury. To assess these differences, we compared the gross and local anatomy and neuromorphology of the lumbar spinal cord of the Wistar and Dark Agouti (DA) strains. The key findings include (i) distinct spatial relationships between vertebrae and spinal segments in the two strains; (ii) Wistar rats have larger volumes of spinal cord gray and white matter; (iii) DA rats have smaller total neuronal populations, thus indicating an expectation of smaller local neuronal populations; (iv) this expectation was confirmed for interneurons expressing calbindin 28 kDa. But contrary to expectations, (v) DA rats had more numerous populations of the interneurons expressing parvalbumin and a population of α-motoneurons. Consequently, these strains displayed divergent ratios in specific spinal neuronal populations. Researchers should consider these inter-strain differences when comparing data across different strains. © 2024 Wiley Periodicals LLC.

AB - Rat strains differ in physiology, behavior, and recovery after central nervous system injury. To assess these differences, we compared the gross and local anatomy and neuromorphology of the lumbar spinal cord of the Wistar and Dark Agouti (DA) strains. The key findings include (i) distinct spatial relationships between vertebrae and spinal segments in the two strains; (ii) Wistar rats have larger volumes of spinal cord gray and white matter; (iii) DA rats have smaller total neuronal populations, thus indicating an expectation of smaller local neuronal populations; (iv) this expectation was confirmed for interneurons expressing calbindin 28 kDa. But contrary to expectations, (v) DA rats had more numerous populations of the interneurons expressing parvalbumin and a population of α-motoneurons. Consequently, these strains displayed divergent ratios in specific spinal neuronal populations. Researchers should consider these inter-strain differences when comparing data across different strains. © 2024 Wiley Periodicals LLC.

KW - calbindin

KW - Dark Agouti

KW - inter-strain differences

KW - parvalbumin

KW - spinal cord

KW - Wistar

KW - α-motoneurons

KW - alpha nerve fiber

KW - Article

KW - cell population

KW - controlled study

KW - dark agouti rat

KW - gray matter

KW - gross anatomy

KW - interneuron

KW - lumbar spinal cord

KW - lumbar spine

KW - male

KW - neuroanatomy

KW - nonhuman

KW - protein expression

KW - rat

KW - rat strain

KW - strain difference

KW - strain identification

KW - white matter

KW - Wistar rat

KW - animal

KW - cytology

KW - lumbar vertebra

KW - metabolism

KW - nerve cell

KW - species difference

KW - Animals

KW - Lumbar Vertebrae

KW - Male

KW - Neurons

KW - Rats

KW - Rats, Wistar

KW - Species Specificity

KW - Spinal Cord

UR - https://www.mendeley.com/catalogue/652da6f4-2856-3dfc-9b77-f4fcba3f9ff0/

U2 - 10.1002/cne.25673

DO - 10.1002/cne.25673

M3 - статья

VL - 532

JO - Journal of Comparative Neurology

JF - Journal of Comparative Neurology

SN - 0021-9967

IS - 10

ER -

ID: 126218813