Interaction of perfluorinated group 13 element Lewis acids E(C6F5)3 (E=B, Al, Ga, In) and Al{OC(CF3)3}3 with diatomic halogens and interhalogens was studied computationally. Boron-containing derivative is predicted to form weak complexes with halogens and to be thermodynamically stable with respect to iodination, while its heavier derivatives form stronger complexes that are unstable with respect to E􀀀 C bond oxidation. The reactivity of E(C6F5)3 with iodine and iodine monochloride and Al{OCR3}3 (R=CF3, C6F5) with iodine was explored experimentally. Experimental data confirm that B(C6F5)3 does not react with ICl at room temperature and with molecular iodine in temperature range 233–350 K. Heavier group 13 element derivatives E(C6F5)3 upon reaction with I2 and ICl undergo oxidation processes with C6F5I evolution. Both Al{OC(CF3)3}3*C6H5F and Al{OC(C6F5)3}3 do not form stable complexes with molecular iodine.