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INTERACTION OF DNA WITH COORDINATION-COMPOUNDS OF BIVALENT PLATINUM .2. EFFECT OF LIGANDS LOCALIZED IN FIRST COORDINATION SPHERE. / KASYANENKO, NA; KARYMOV, MA; DYACHENKO, SA; SMORYGO, NA; FRISMAN, EV.

In: Molecular Biology, Vol. 29, No. 3, 1995, p. 340-347.

Research output: Contribution to journal › Article › peer-review

Harvard

KASYANENKO, NA, KARYMOV, MA, DYACHENKO, SA, SMORYGO, NA & FRISMAN, EV 1995, 'INTERACTION OF DNA WITH COORDINATION-COMPOUNDS OF BIVALENT PLATINUM .2. EFFECT OF LIGANDS LOCALIZED IN FIRST COORDINATION SPHERE', Molecular Biology, vol. 29, no. 3, pp. 340-347.

APA

KASYANENKO, NA., KARYMOV, MA., DYACHENKO, SA., SMORYGO, NA., & FRISMAN, EV. (1995). INTERACTION OF DNA WITH COORDINATION-COMPOUNDS OF BIVALENT PLATINUM .2. EFFECT OF LIGANDS LOCALIZED IN FIRST COORDINATION SPHERE. Molecular Biology, 29(3), 340-347.

Vancouver

KASYANENKO NA, KARYMOV MA, DYACHENKO SA, SMORYGO NA, FRISMAN EV. INTERACTION OF DNA WITH COORDINATION-COMPOUNDS OF BIVALENT PLATINUM .2. EFFECT OF LIGANDS LOCALIZED IN FIRST COORDINATION SPHERE. Molecular Biology. 1995;29(3):340-347.

Author

KASYANENKO, NA ; KARYMOV, MA ; DYACHENKO, SA ; SMORYGO, NA ; FRISMAN, EV. / INTERACTION OF DNA WITH COORDINATION-COMPOUNDS OF BIVALENT PLATINUM .2. EFFECT OF LIGANDS LOCALIZED IN FIRST COORDINATION SPHERE. In: Molecular Biology. 1995 ; Vol. 29, No. 3. pp. 340-347.

BibTeX

@article{2552223eb4194ed7afd741f0bc653ca3,
title = "INTERACTION OF DNA WITH COORDINATION-COMPOUNDS OF BIVALENT PLATINUM .2. EFFECT OF LIGANDS LOCALIZED IN FIRST COORDINATION SPHERE",
abstract = "Interaction of DNA with cis- and trans-diaminodichloroplatinum (DDP), [(NH4)(4)Pt]Cl-2, and K2PtCl4 was studied. It was found that binding of cis- and trans-DDP and [PtCl4](2-) to DNA involves formation of aquacomplexes. The departing chlorine atoms play an important role in complex formation. For cis-DDP, two nucleic base groups are inserted into the platinum first coordination sphere. The complex is stabilized by the DNA phosphates shielding the positive charges in the outer coordination sphere. For trans-DDP, the localization of the platinum acido ligands and the amino groups does not favor formation of a bidentate,complex with the nucleic bases of DNA. The presence of two DNA-binding sites in the [PtCl4](2-) aquacomplexes does not stabilize the latter. No coordination bonds can be formed between [(NH)(4)Pt]Cl-2 and DNA, because the envelope groups of the [(NH)(4)Pt](2+) ion cannot be substituted. This ion interacts with DNA, but the mechanism of this interaction is different from that for DNA and cis-DDP.",
keywords = "DNA, PLATINUM, VISCOSIMETRY, DYNAMIC BIREFRINGENCE",
author = "NA KASYANENKO and MA KARYMOV and SA DYACHENKO and NA SMORYGO and EV FRISMAN",
year = "1995",
language = "Английский",
volume = "29",
pages = "340--347",
journal = "Molecular Biology",
issn = "0026-8933",
publisher = "Pleiades Publishing",
number = "3",

}

RIS

TY - JOUR

T1 - INTERACTION OF DNA WITH COORDINATION-COMPOUNDS OF BIVALENT PLATINUM .2. EFFECT OF LIGANDS LOCALIZED IN FIRST COORDINATION SPHERE

AU - KASYANENKO, NA

AU - KARYMOV, MA

AU - DYACHENKO, SA

AU - SMORYGO, NA

AU - FRISMAN, EV

PY - 1995

Y1 - 1995

N2 - Interaction of DNA with cis- and trans-diaminodichloroplatinum (DDP), [(NH4)(4)Pt]Cl-2, and K2PtCl4 was studied. It was found that binding of cis- and trans-DDP and [PtCl4](2-) to DNA involves formation of aquacomplexes. The departing chlorine atoms play an important role in complex formation. For cis-DDP, two nucleic base groups are inserted into the platinum first coordination sphere. The complex is stabilized by the DNA phosphates shielding the positive charges in the outer coordination sphere. For trans-DDP, the localization of the platinum acido ligands and the amino groups does not favor formation of a bidentate,complex with the nucleic bases of DNA. The presence of two DNA-binding sites in the [PtCl4](2-) aquacomplexes does not stabilize the latter. No coordination bonds can be formed between [(NH)(4)Pt]Cl-2 and DNA, because the envelope groups of the [(NH)(4)Pt](2+) ion cannot be substituted. This ion interacts with DNA, but the mechanism of this interaction is different from that for DNA and cis-DDP.

AB - Interaction of DNA with cis- and trans-diaminodichloroplatinum (DDP), [(NH4)(4)Pt]Cl-2, and K2PtCl4 was studied. It was found that binding of cis- and trans-DDP and [PtCl4](2-) to DNA involves formation of aquacomplexes. The departing chlorine atoms play an important role in complex formation. For cis-DDP, two nucleic base groups are inserted into the platinum first coordination sphere. The complex is stabilized by the DNA phosphates shielding the positive charges in the outer coordination sphere. For trans-DDP, the localization of the platinum acido ligands and the amino groups does not favor formation of a bidentate,complex with the nucleic bases of DNA. The presence of two DNA-binding sites in the [PtCl4](2-) aquacomplexes does not stabilize the latter. No coordination bonds can be formed between [(NH)(4)Pt]Cl-2 and DNA, because the envelope groups of the [(NH)(4)Pt](2+) ion cannot be substituted. This ion interacts with DNA, but the mechanism of this interaction is different from that for DNA and cis-DDP.

KW - DNA

KW - PLATINUM

KW - VISCOSIMETRY

KW - DYNAMIC BIREFRINGENCE

M3 - статья

VL - 29

SP - 340

EP - 347

JO - Molecular Biology

JF - Molecular Biology

SN - 0026-8933

IS - 3

ER -

ID: 73400387