The article deals with the integral assessment of the state and sustainability of socio-ecological and economic systems (SEES). The integral assessment of SEES, 9 regions of the Arctic Zone of the RF (AZR) and one region of the central Russia (Tver Region) is used as a foundation for the analysis of the state of SEES and the quality of life of the population, as well as the ability of SEESs to maintain their properties and quantitative characteristics in case of an external impact on the system or any intrasystem changes. Eight scenarios of impact on subsystems and systems as a whole at the regional level were developed to assess sustainability. The article presents the results of the evaluation of the quality of environment and the quality of life of the population in the regions in 2003-2015. The main goal of the study was to identify situations in which SEES, upon the impact assigned upon it, will not be able to maintain its properties and parameters and will move to another class, both in separate subsystems and as the whole system.