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Insect Antimicrobial Peptide Complexes Prevent Resistance Development in Bacteria. / Chernysh, S.; Gordya, N.; Suborova, T.

In: PLoS ONE, 2015, p. 1-15.

Research output: Contribution to journal › Article

Harvard

Chernysh, S, Gordya, N & Suborova, T 2015, 'Insect Antimicrobial Peptide Complexes Prevent Resistance Development in Bacteria', PLoS ONE, pp. 1-15. https://doi.org/10.1371/journal.pone.0130788

APA

Chernysh, S., Gordya, N., & Suborova, T. (2015). Insect Antimicrobial Peptide Complexes Prevent Resistance Development in Bacteria. PLoS ONE, 1-15. https://doi.org/10.1371/journal.pone.0130788

Vancouver

Chernysh S, Gordya N, Suborova T. Insect Antimicrobial Peptide Complexes Prevent Resistance Development in Bacteria. PLoS ONE. 2015;1-15. https://doi.org/10.1371/journal.pone.0130788

Author

Chernysh, S. ; Gordya, N. ; Suborova, T. / Insect Antimicrobial Peptide Complexes Prevent Resistance Development in Bacteria. In: PLoS ONE. 2015 ; pp. 1-15.

BibTeX

@article{dc593c5f03d94be5b2aca89f551844b5,
title = "Insect Antimicrobial Peptide Complexes Prevent Resistance Development in Bacteria",
abstract = "In recent decades much attention has been paid to antimicrobial peptides (AMPs) as natural antibiotics, which are presumably protected from resistance development in bacteria. However, experimental evolution studies have revealed prompt resistance increase in bacteria to any individual AMP tested. Here we demonstrate that naturally occurring compounds containing insect AMP complexes have clear advantage over individual peptide and small molecule antibiotics in respect of drug resistance development. As a model we have used the compounds isolated from bacteria challenged maggots of Calliphoridae flies. The compound isolated from blow fly Calliphora vicina was found to contain three distinct families of cell membrane is rupting/permeabilizing peptides (defensins, cecropins and diptericins), one family of proline rich peptides and several unknown antimicrobial substances. Resistance changes under long term selective pressure of the compound and reference antibiotics cefotaxime, meropenem and polymyxin B were te",
author = "S. Chernysh and N. Gordya and T. Suborova",
year = "2015",
doi = "10.1371/journal.pone.0130788",
language = "English",
pages = "1--15",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",

}

RIS

TY - JOUR

T1 - Insect Antimicrobial Peptide Complexes Prevent Resistance Development in Bacteria

AU - Chernysh, S.

AU - Gordya, N.

AU - Suborova, T.

PY - 2015

Y1 - 2015

N2 - In recent decades much attention has been paid to antimicrobial peptides (AMPs) as natural antibiotics, which are presumably protected from resistance development in bacteria. However, experimental evolution studies have revealed prompt resistance increase in bacteria to any individual AMP tested. Here we demonstrate that naturally occurring compounds containing insect AMP complexes have clear advantage over individual peptide and small molecule antibiotics in respect of drug resistance development. As a model we have used the compounds isolated from bacteria challenged maggots of Calliphoridae flies. The compound isolated from blow fly Calliphora vicina was found to contain three distinct families of cell membrane is rupting/permeabilizing peptides (defensins, cecropins and diptericins), one family of proline rich peptides and several unknown antimicrobial substances. Resistance changes under long term selective pressure of the compound and reference antibiotics cefotaxime, meropenem and polymyxin B were te

AB - In recent decades much attention has been paid to antimicrobial peptides (AMPs) as natural antibiotics, which are presumably protected from resistance development in bacteria. However, experimental evolution studies have revealed prompt resistance increase in bacteria to any individual AMP tested. Here we demonstrate that naturally occurring compounds containing insect AMP complexes have clear advantage over individual peptide and small molecule antibiotics in respect of drug resistance development. As a model we have used the compounds isolated from bacteria challenged maggots of Calliphoridae flies. The compound isolated from blow fly Calliphora vicina was found to contain three distinct families of cell membrane is rupting/permeabilizing peptides (defensins, cecropins and diptericins), one family of proline rich peptides and several unknown antimicrobial substances. Resistance changes under long term selective pressure of the compound and reference antibiotics cefotaxime, meropenem and polymyxin B were te

U2 - 10.1371/journal.pone.0130788

DO - 10.1371/journal.pone.0130788

M3 - Article

SP - 1

EP - 15

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

ER -

ID: 3980841