Research output: Contribution to journal › Article › peer-review
Injectable self-healing nanocellulose hydrogels crosslinked by aluminum: Cellulose nanocrystals vs. cellulose nanofibrils. / Lin, Zhongxin; Huang, Renliang; Wu, Jiangjiexing; Пенькова, Анастасия Владимировна; Qi, Wei; He, Zhimin; Su, Rongxin.
In: Chinese Journal of Chemical Engineering, Vol. 50, 01.10.2022, p. 389-397.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Injectable self-healing nanocellulose hydrogels crosslinked by aluminum: Cellulose nanocrystals vs. cellulose nanofibrils
AU - Lin, Zhongxin
AU - Huang, Renliang
AU - Wu, Jiangjiexing
AU - Пенькова, Анастасия Владимировна
AU - Qi, Wei
AU - He, Zhimin
AU - Su, Rongxin
N1 - Publisher Copyright: © 2022 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd
PY - 2022/10/1
Y1 - 2022/10/1
N2 - With excellent biocompatibility and unique physiochemical properties, nanocelluloses including cellulose nanocrystals (CNCs) and cellulose nanofibrils (CNFs) are promising candidates for preparing biomedical hydrogels. CNCs and CNFs are different in morphology and surface charges. Herein, CNCs and two CNFs (CNFs-C, Carboxylated CNFs; CNFs-P, Phosphorylated CNFs) were synthesized and applied to fabricate hydrogels through metal crosslinking. Aluminum crosslinking was found to be the best choice for enhancing the strength. This study systematically compared the morphologies, storage modulus, loss factor, continuous shear ramp, self-healing, swelling, in vitro degradation and injectable properties of the fabricated hydrogels. Further, a radar chart is summarized as guidelines to direct the rational selection to meet the specific requirements of further biomedical applications. At the same nanocellulose concentration and after Al 3+ crosslinking, CNCs hydrogels had strong water holding capacity twice as much as that of CNFs hydrogels. While CNFs hydrogels showed higher hardness and stronger resistance to degradation than that of CNCs. These results provide detailed insights into nanocellulose hydrogels, making it possible to use these guidelines to select hydrogels for desired performance.
AB - With excellent biocompatibility and unique physiochemical properties, nanocelluloses including cellulose nanocrystals (CNCs) and cellulose nanofibrils (CNFs) are promising candidates for preparing biomedical hydrogels. CNCs and CNFs are different in morphology and surface charges. Herein, CNCs and two CNFs (CNFs-C, Carboxylated CNFs; CNFs-P, Phosphorylated CNFs) were synthesized and applied to fabricate hydrogels through metal crosslinking. Aluminum crosslinking was found to be the best choice for enhancing the strength. This study systematically compared the morphologies, storage modulus, loss factor, continuous shear ramp, self-healing, swelling, in vitro degradation and injectable properties of the fabricated hydrogels. Further, a radar chart is summarized as guidelines to direct the rational selection to meet the specific requirements of further biomedical applications. At the same nanocellulose concentration and after Al 3+ crosslinking, CNCs hydrogels had strong water holding capacity twice as much as that of CNFs hydrogels. While CNFs hydrogels showed higher hardness and stronger resistance to degradation than that of CNCs. These results provide detailed insights into nanocellulose hydrogels, making it possible to use these guidelines to select hydrogels for desired performance.
KW - Cellulose nanocrystals
KW - Cellulose nanofibrils
KW - Fabrication
KW - Gels
KW - Mechanical properties
KW - Surface heterogeneities
UR - http://www.scopus.com/inward/record.url?scp=85139352222&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/239bcf3b-7ad0-3538-ba72-8d7646e02999/
U2 - 10.1016/j.cjche.2022.04.026
DO - 10.1016/j.cjche.2022.04.026
M3 - Article
VL - 50
SP - 389
EP - 397
JO - Chinese Journal of Chemical Engineering
JF - Chinese Journal of Chemical Engineering
SN - 1004-9541
ER -
ID: 99549884