Research output: Contribution to journal › Article › peer-review
Infrared Spectroscopy of Blood Serum from Patients with Multiple Myeloma. / Plotnikova, L. V. ; Kobeleva, M. O. ; Borisov, E. V. ; Garifullin, A. D. ; Povolotskaya, A. V. ; Voloshin, S. V. ; Polyanichko, A. M. .
In: Cell and Tissue Biology, Vol. 13, No. 2, 2019, p. 130-135.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Infrared Spectroscopy of Blood Serum from Patients with Multiple Myeloma
AU - Plotnikova, L. V.
AU - Kobeleva, M. O.
AU - Borisov, E. V.
AU - Garifullin, A. D.
AU - Povolotskaya, A. V.
AU - Voloshin, S. V.
AU - Polyanichko, A. M.
N1 - Plotnikova, L.V., Kobeleva, M.O., Borisov, E.V. et al. Infrared Spectroscopy of Blood Serum from Patients with Multiple Myeloma. Cell Tiss. Biol. 13, 130–135 (2019). https://doi.org/10.1134/S1990519X19020093
PY - 2019
Y1 - 2019
N2 - Abstract: A combination of high-resolution agarose gel protein electrophoresis, refractometric analysis, and infrared spectroscopy was applied to investigate the blood serum in patients with multiple myeloma (MM). Analysis of the FTIR spectra of the serum obtained from MM patients and healthy donors revealed a decreased amount of α-helixes and increased content of β-sheets in serum proteins from MM patients compared to healthy donors. These findings suggest an interaction between serum proteins and stabilization of the resulting complexes, accompanied by the formation of associated β-sheets.
AB - Abstract: A combination of high-resolution agarose gel protein electrophoresis, refractometric analysis, and infrared spectroscopy was applied to investigate the blood serum in patients with multiple myeloma (MM). Analysis of the FTIR spectra of the serum obtained from MM patients and healthy donors revealed a decreased amount of α-helixes and increased content of β-sheets in serum proteins from MM patients compared to healthy donors. These findings suggest an interaction between serum proteins and stabilization of the resulting complexes, accompanied by the formation of associated β-sheets.
KW - FTIR spectroscopy
KW - multiple myeloma
KW - secondary structure
UR - http://www.scopus.com/inward/record.url?scp=85066154393&partnerID=8YFLogxK
U2 - 10.1134/S1990519X19020093
DO - 10.1134/S1990519X19020093
M3 - Article
VL - 13
SP - 130
EP - 135
JO - Cell and Tissue Biology
JF - Cell and Tissue Biology
SN - 1990-519X
IS - 2
ER -
ID: 39015191